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A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis

Author

Listed:
  • Itxaso González-Ortega

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain
    Department of Personality, Assessment and Psychological Treatment, National University of Distance Education (UNED), 01008 Vitoria, Spain
    Department of Neurosciences, University of the Basque Country, 48940 Leioa, Spain)

  • Patricia Vega

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain
    Department of Neurosciences, University of the Basque Country, 48940 Leioa, Spain)

  • Enrique Echeburúa

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Department of Personality, Assessment and Psychological Treatment, University of the Basque Country, Biodonostia, 20018 San Sebastian, Spain)

  • Susana Alberich

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain
    Department of Fundamental Mathematics, National University of Distance Education (UNED), 01008 Vitoria, Spain)

  • Jessica Fernández-Sevillano

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain
    Department of Neurosciences, University of the Basque Country, 48940 Leioa, Spain)

  • Sara Barbeito

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Department of Psychology, International University of La Rioja (UNIR), 26006 Logroño, Spain)

  • Vicent Balanzá-Martínez

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Teaching Unit of Psychiatry, Department of Medicine, University of Valencia Medical School, 46010 Valencia, Spain)

  • Eduard Vieta

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Department of Psychiatry, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, 08036 Barcelona, Spain)

  • Esther Lorente-Rovira

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Department of Psychiatry, Clinic University Hospital of Valencia, INCLIVA, 46010 Valencia, Spain)

  • Ana Luengo

    (Department of Psychiatry, Clinic University Hospital of Valencia, INCLIVA, 46010 Valencia, Spain)

  • Ester Cerrillo

    (Department of Psychiatry, Bellvitge University Hospital, IDIBELL, 08907 Barcelona, Spain)

  • José Manuel Crespo

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Department of Psychiatry, Bellvitge University Hospital, IDIBELL, 08907 Barcelona, Spain)

  • Carlos Matute

    (Achucarro Basque Centre for Neurosciences, University of the Basque Country, 48940 Leioa, Spain
    Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 48940 Leioa, Spain)

  • Ana González-Pinto

    (Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
    Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain
    Department of Neurosciences, University of the Basque Country, 48940 Leioa, Spain)

Abstract

Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The aim of this study was to compare the efficacy of a combined clinical treatment involving Cognitive Behavioural Therapy (CBT) as an adjunctive to treatment-as-usual (TAU) (CBT+TAU) versus TAU alone for FEP. Patients and methods: In this multicentre, single-blind, randomised controlled trial, 177 participants were randomly allocated to either CBT+TAU or TAU. The primary outcome was post-treatment patient functioning. Results: The CBT+TAU group showed a greater improvement in functioning, which was measured using the Global Assessment Functioning (GAF) and Functioning Assessment Short Test (FAST), compared to the TAU group post-treatment. The CBT+TAU participants exhibited a greater decline in depressive, negative, and general psychotic symptoms; a better awareness of the disease and treatment adherence; and a greater increase in brain-derived neurotrophic factor levels than TAU participants. Conclusions: Early intervention based on a combined clinical treatment involving CBT as an adjunctive to standard treatment may improve clinical and functional outcomes in FEP.

Suggested Citation

  • Itxaso González-Ortega & Patricia Vega & Enrique Echeburúa & Susana Alberich & Jessica Fernández-Sevillano & Sara Barbeito & Vicent Balanzá-Martínez & Eduard Vieta & Esther Lorente-Rovira & Ana Luengo, 2021. "A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis," IJERPH, MDPI, vol. 18(14), pages 1-13, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7239-:d:589601
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    References listed on IDEAS

    as
    1. Jason Randall & Dan Chateau & James M Bolton & Mark Smith & Laurence Katz & Elaine Burland & Carole Taylor & Nathan C Nickel & Jennifer Enns & Alan Katz & Marni Brownell & the PATHS Equity Team, 2017. "Increasing medication adherence and income assistance access for first-episode psychosis patients," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-11, June.
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    Cited by:

    1. Anna Mosiołek & Jadwiga Mosiołek, 2023. "The Effects of Treatment in Psychotic Disorders—Changes in BDNF Levels and Clinical Outcomes: Systematic Review," IJERPH, MDPI, vol. 20(3), pages 1-15, January.
    2. Itxaso González-Ortega & Enrique Echeburúa & Susana Alberich & Miguel Bernardo & Eduard Vieta & Gonzalo Salazar de Pablo & Ana González-Pinto, 2022. "Cognitive Behavioral Therapy Program for Cannabis Use Cessation in First-Episode Psychosis Patients: A 1-Year Randomized Controlled Trial," IJERPH, MDPI, vol. 19(12), pages 1-19, June.

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