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Baseline Optical Coherence Tomography Parameters That May Influence 6 Months Treatment Outcome of Polypoidal Choroidal Vasculopathy Eyes with Combination Therapy: A Short-Term Pilot Study

Author

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  • Rituparna Ghoshal

    (Optometry & Vision Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    Department of Optometry, C T University, Ferozepur Road, Sidhwan Khurd 142024, Ludhiana, Punjab, India)

  • Sharanjeet Sharanjeet-Kaur

    (Optometry & Vision Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Norliza Mohamad Fadzil

    (Optometry & Vision Science Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Somnath Ghosh

    (Department of Allied Health Sciences, Brainware University, Barasat, Kalkata 700125, West Bengal, India)

  • NorFariza Ngah

    (Department of Ophthalmology, Hospital Shah Alam, Persiaran Kayangan, Seksyen 7, Shah Alam 40000, Malaysia)

  • Roslin Azni Abd Aziz

    (Department of Ophthalmology, Hospital Shah Alam, Persiaran Kayangan, Seksyen 7, Shah Alam 40000, Malaysia)

Abstract

Although optical coherence tomography (OCT) parameters have assisted in the diagnosis of polypoidal choroidal vasculopathy (PCV), its potential to evaluate treatment outcomes has not been established. The purpose of this pilot study was to evaluate baseline OCT parameters that may influence treatment outcome in PCV eyes with combination therapy. In this single-centered, prospective study, patients were recruited with at least one treatment-naïve PCV eye and treated with combination therapy of intravitreal anti-vascular endothelial growth factor and photodynamic therapy. Best-corrected distance and near visual acuity (DVA and NVA), and contrast sensitivity (CS) were recorded at baseline and six months after treatment. OCT parameters were determined. Twenty-six eyes of 26 patients aged between 51 to 83 years were evaluated. In eyes that had disrupted external limiting membrane (ELM), photoreceptors inner and outer segment (IS-OS) junction at 1000 micron of fovea at baseline showed low mean visual functions after 6 months of treatment. Eyes with foveal sub-retinal fluid (SRF) and polyp at central 1000 micron of fovea at baseline showed significantly worse DVA and CS after six months. Thus, the presence of foveal SRF, foveal polyp, disrupted ELM, and IS-OS junction at baseline significantly influenced the six months’ visual outcome in PCV eyes treated with combination therapy.

Suggested Citation

  • Rituparna Ghoshal & Sharanjeet Sharanjeet-Kaur & Norliza Mohamad Fadzil & Somnath Ghosh & NorFariza Ngah & Roslin Azni Abd Aziz, 2021. "Baseline Optical Coherence Tomography Parameters That May Influence 6 Months Treatment Outcome of Polypoidal Choroidal Vasculopathy Eyes with Combination Therapy: A Short-Term Pilot Study," IJERPH, MDPI, vol. 18(10), pages 1-9, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:10:p:5378-:d:557054
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    References listed on IDEAS

    as
    1. Rituparna Ghoshal & Sharanjeet Sharanjeet-Kaur & Norliza Mohamad Fadzil & Somnath Ghosh & Nor Fariza Ngah & Roslin Azni Abd Aziz, 2020. "Patient-Perceived Benefit of Treatment in Polypoidal Choroidal Vasculopathy: A Pilot Study," IJERPH, MDPI, vol. 17(17), pages 1-9, September.
    2. Rituparna Ghoshal & Sharanjeet Sharanjeet-Kaur & Norliza Mohamad Fadzil & Haliza Abdul Mutalib & Somnath Ghosh & Nor Fariza Ngah & Roslin Azni Abd Aziz, 2020. "Correlation between Visual Functions and Retinal Morphology in Eyes with Early and Intermediate Age-Related Macular Degeneration," IJERPH, MDPI, vol. 17(17), pages 1-14, September.
    3. Rituparna Ghoshal & Sharanjeet Sharanjeet-Kaur & Norliza Mohamad Fadzil & Somnath Ghosh & Nor Fariza Ngah & Roslin Azni Binti Abd Aziz, 2021. "Visual Parameters and Retinal Morphology for Polypoidal Choroidal Vasculopathy Pre- and Post-Intravitreal Ranibizumab with or without Photodynamic Therapy: A Short-Term Prospective Study," IJERPH, MDPI, vol. 18(5), pages 1-10, March.
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