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Correlation between Visual Functions and Retinal Morphology in Eyes with Early and Intermediate Age-Related Macular Degeneration

Author

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  • Rituparna Ghoshal

    (Optometry and Vision Science Program, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    Department of Optometry, Supreme Institute of Management and Technology, Mankundu Hooghly 712123, West Bengal, India)

  • Sharanjeet Sharanjeet-Kaur

    (Optometry and Vision Science Program, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Norliza Mohamad Fadzil

    (Optometry and Vision Science Program, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Haliza Abdul Mutalib

    (Optometry and Vision Science Program, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Somnath Ghosh

    (Department of Allied Health Sciences, Brainware University, Barasat, Kalkata 700125, West Bengal, India)

  • Nor Fariza Ngah

    (Department of Ophthalmology, Hospital Shah Alam, Persiaran Kayangan, Seksyen 7, Shah Alam 40000, Selangor, Malaysia)

  • Roslin Azni Abd Aziz

    (Department of Ophthalmology, Hospital Shah Alam, Persiaran Kayangan, Seksyen 7, Shah Alam 40000, Selangor, Malaysia)

Abstract

In early and intermediate age related macular degeneration (ARMD), visual acuity alone has failed to explain the complete variation of vision. The aim of the present study was to determine correlation between different visual functions and retinal morphology in eyes with early and intermediate ARMD. In this single center cross sectional study, patients diagnosed as early or intermediate ARMD in at least one eye were recruited. Visual functions measured were best- corrected distance visual acuity (DVA), near vision acuity (NVA), reading speed (RS), and contrast sensitivity (CS). Parameters such as thickness (RT) and volume (RV) of the retina, outer retinal layer thickness (ORLT) and volume (ORLV), outer nuclear layer thickness (ONLT) and volume (ONLV), retinal pigment epithelium layer-Bruch’s membrane complex thickness (RPET) and volume (RPEV) were assessed employing semi-auto segmentation method of Spectralis optical coherence tomography (OCT). Twenty-six eyes were evaluated. DVA, CS, and RS showed significantly good correlation with RPET, ONLT, and ONLV, whereas NVA showed good correlation with ONLV and RPET. The present study concluded that RS, CS, NVA, and DVA represent the morphological alteration in early stages and should be tested in clinical settings. ONLT, ONLV, and RPET morphological parameters can be employed as important biomarkers in diagnosis of early to intermediate ARMD.

Suggested Citation

  • Rituparna Ghoshal & Sharanjeet Sharanjeet-Kaur & Norliza Mohamad Fadzil & Haliza Abdul Mutalib & Somnath Ghosh & Nor Fariza Ngah & Roslin Azni Abd Aziz, 2020. "Correlation between Visual Functions and Retinal Morphology in Eyes with Early and Intermediate Age-Related Macular Degeneration," IJERPH, MDPI, vol. 17(17), pages 1-14, September.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:17:p:6379-:d:407503
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    Cited by:

    1. Rituparna Ghoshal & Sharanjeet Sharanjeet-Kaur & Norliza Mohamad Fadzil & Somnath Ghosh & NorFariza Ngah & Roslin Azni Abd Aziz, 2021. "Baseline Optical Coherence Tomography Parameters That May Influence 6 Months Treatment Outcome of Polypoidal Choroidal Vasculopathy Eyes with Combination Therapy: A Short-Term Pilot Study," IJERPH, MDPI, vol. 18(10), pages 1-9, May.

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