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Development of Osteoporosis Screening Algorithm for Population Aged 50 Years and above in Klang Valley, Malaysia

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  • Shaanthana Subramaniam

    (Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia)

  • Chin-Yi Chan

    (Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia)

  • Ima-Nirwana Soelaiman

    (Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia)

  • Norazlina Mohamed

    (Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia)

  • Norliza Muhammad

    (Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia)

  • Fairus Ahmad

    (Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia)

  • Pei-Yuen Ng

    (Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Nor Aini Jamil

    (Centre for Community Health Studies, Faculty of Health Science, Universiti Kebangsaan Malaysia Kuala Lumpur Campus Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Noorazah Abd Aziz

    (Department of Family Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia)

  • Kok-Yong Chin

    (Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Malaysia)

Abstract

Background: The current osteoporosis screening instruments are not optimized to be used among the Malaysian population. This study aimed to develop an osteoporosis screening algorithm based on risk factors for Malaysians. Methods: Malaysians aged ≥50 years (n = 607) from Klang Valley, Malaysia were interviewed and their bone health status was assessed using a dual-energy X-ray absorptiometry device. The algorithm was constructed based on osteoporosis risk factors using multivariate logistic regression and its performance was assessed using receiver operating characteristics analysis. Results: Increased age, reduced body weight and being less physically active significantly predicted osteoporosis in men, while in women, increased age, lower body weight and low-income status significantly predicted osteoporosis. These factors were included in the final algorithm and the optimal cut-offs to identify subjects with osteoporosis was 0.00120 for men [sensitivity 73.3% (95% confidence interval (CI) = 54.1%–87.7%), specificity 67.8% (95% CI = 62.7%–85.5%), area under curve (AUC) 0.705 (95% CI = 0.608–0.803), p < 0.001] and 0.161 for women [sensitivity 75.4% (95% CI = 61.9%–73.3%), specificity 74.5% (95% CI = 68.5%–79.8%), AUC 0.749 (95% CI = 0.679–0.820), p < 0.001]. Conclusion: The new algorithm performed satisfactorily in identifying the risk of osteoporosis among the Malaysian population ≥50 years. Further validation studies are required before applying this algorithm for screening of osteoporosis in public.

Suggested Citation

  • Shaanthana Subramaniam & Chin-Yi Chan & Ima-Nirwana Soelaiman & Norazlina Mohamed & Norliza Muhammad & Fairus Ahmad & Pei-Yuen Ng & Nor Aini Jamil & Noorazah Abd Aziz & Kok-Yong Chin, 2020. "Development of Osteoporosis Screening Algorithm for Population Aged 50 Years and above in Klang Valley, Malaysia," IJERPH, MDPI, vol. 17(7), pages 1-12, April.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:7:p:2526-:d:342400
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    References listed on IDEAS

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    1. Chin Yi Chan & Shaanthana Subramaniam & Kok-Yong Chin & Soelaiman Ima-Nirwana & Norliza Muhammad & Ahmad Fairus & Pei Yuen Ng & Nor Aini Jamil & Noorazah Abd Aziz & Norazlina Mohamed, 2019. "Levels of Knowledge, Beliefs, and Practices Regarding Osteoporosis and the Associations with Bone Mineral Density among Populations More Than 40 Years Old in Malaysia," IJERPH, MDPI, vol. 16(21), pages 1-22, October.
    2. Chin Yi Chan & Shaanthana Subramaniam & Kok-Yong Chin & Soelaiman Ima-Nirwana & Norliza Muhammad & Ahmad Fairus & Abdul Manap Mohd Rizal & Pei Yuan Ng & Jamil Nor Aini & Noorazah Abd Aziz & Norazlina , 2019. "Knowledge, Beliefs, Dietary, and Lifestyle Practices Related to Bone Health among Middle-Aged and Elderly Chinese in Klang Valley, Malaysia," IJERPH, MDPI, vol. 16(10), pages 1-20, May.
    3. Kok-Yong Chin & Nie Yen Low & Wan Ilma Dewiputri & Soelaiman Ima-Nirwanaa, 2017. "Factors Associated with Bone Health in Malaysian Middle-Aged and Elderly Women Assessed via Quantitative Ultrasound," IJERPH, MDPI, vol. 14(7), pages 1-13, July.
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    1. Chin Yi Chan & Shaanthana Subramaniam & Kok-Yong Chin & Soelaiman Ima-Nirwana & Norliza Muhammad & Ahmad Fairus & Pei Yuen Ng & Jamil Nor Aini & Noorazah Abd Aziz & Norazlina Mohamed, 2022. "Effect of a Screening and Education Programme on Knowledge, Beliefs, and Practices Regarding Osteoporosis among Malaysians," IJERPH, MDPI, vol. 19(10), pages 1-16, May.

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