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Supplementation with a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity

Author

Listed:
  • Marion Saby

    (EA7288 UFR Pharmacie, Université de Montpellier, CEDEX 5, 34093 Montpellier, France)

  • Audrey Gauthier

    (Bionov Research, 939 rue de la croix verte, 34090 Montpellier, France)

  • Sandy Barial

    (EA7288 UFR Pharmacie, Université de Montpellier, CEDEX 5, 34093 Montpellier, France)

  • Laure Egoumenides

    (Bionov Research, 939 rue de la croix verte, 34090 Montpellier, France)

  • Bernard Jover

    (PhyMedExp, INSERM CNRS, Université de Montpellier, IURC, CEDEX 5, 34295 Montpellier, France)

Abstract

Exercise is recognized to provide both physical and psychological health benefits. However, oxidative stress can occur and induce muscular damages. SOD B ® ; M is a melon concentrate, well known to counteract oxidative stress and prevent its side effects. The present study aimed to evaluate the potential of the melon concentrate in the context of both a strong and isolated effort associated with deleterious effects, and a moderate and regular physical activity considered as beneficial. First, a preclinical study was set up on rats to evaluate its potential on the prevention of damages induced by an eccentric exercise. Secondly, the combined effect of the melon concentrate and a regular standardized physical training was studied on the overall physical condition of healthy subjects in a randomized, double-blind, placebo-controlled trial. Repeated measures Analysis of Variance (ANOVA), student’s t test and Mann–Whitney test were used for statistical analyses. Melon concentrate helped to prevent gastrocnemius damages induced by the eccentric exercise. It allowed a reduction of fibrosis by approximately 38% and a reduction of Tumor Necrosis Factor- α (TNF-α) plasma level by 28%. This supplementation also induced a rearrangement of myosin fibers and an increase in PGC-1α plasma level. In the clinical study, melon concentrate was able to decrease oxidative stress and C-Reactive protein (CRP) plasma level. Besides, magnesium (Mg) plasma level was higher in the context of a regular training performed by healthy subjects supplemented with the melon concentrate. Therefore, the melon concentrate allowed a better adaptation to effort linked to PGC-1α activation: a regulator of energy metabolism. The antioxidant properties of the melon concentrate and its ability to mobilize magnesium also suggest that the supplementation could induce a better resistance to fatigue and recovery during regular physical activity.

Suggested Citation

  • Marion Saby & Audrey Gauthier & Sandy Barial & Laure Egoumenides & Bernard Jover, 2020. "Supplementation with a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity," IJERPH, MDPI, vol. 17(4), pages 1-17, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1142-:d:319083
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    References listed on IDEAS

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    1. Schulenkorf, Nico & Siefken, Katja, 2019. "Managing sport-for-development and healthy lifestyles: The sport-for-health model," Sport Management Review, Elsevier, vol. 22(1), pages 96-107.
    2. Nico Schulenkorf & Katja Siefken, 2019. "Managing sport-for-development and healthy lifestyles: The sport-for-health model," Sport Management Review, Taylor & Francis Journals, vol. 22(1), pages 96-107, January.
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