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First Report of Canine Infection by Leishmania ( Viannia ) guyanensis in the Brazilian Amazon

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  • Francisco J. A. Santos

    (Seção de Parasitologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua 67030-000, Pará, Brazil)

  • Luciana C. S. Nascimento

    (Seção de Parasitologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua 67030-000, Pará, Brazil
    Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém 66095-662, Pará, Brazil)

  • Wellington B. Silva

    (Centro Nacional de Primatas, Instituto Evandro Chagas, Ministério da Saúde, Secretaria de Vigilância em Saúde, Ananindeua 67030-000, Pará, Brazil)

  • Luciana P. Oliveira

    (Seção de Parasitologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua 67030-000, Pará, Brazil)

  • Walter S. Santos

    (Seção de Parasitologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua 67030-000, Pará, Brazil)

  • Délia C. F. Aguiar

    (Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil)

  • Lourdes M. Garcez

    (Seção de Parasitologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua 67030-000, Pará, Brazil
    Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém 66095-662, Pará, Brazil)

Abstract

The American cutaneous (CL) and visceral leishmaniasis (VL) are zooanthroponoses transmitted by sand flies. Brazil records thousands of human leishmaniasis cases annually. Dogs are reservoirs of Leishmania infantum , which causes VL, but their role in the transmission cycle of CL is debatable. Wild mammals are considered reservoirs of the aetiological agents of CL ( Leishmania spp.). Objective: To describe the aetiology of leishmaniasis in dogs in an endemic area for CL and VL in the Amazon, Brazil. Methods: Clinical evaluation and blood collection of 40 dogs from the villages Ubim (20) and Socorro (20), city of Tomé-Açu, state of Pará, were carried out. The DNA extracted from the blood was used for PCR with Leishmania -specific primers targeting the hsp70-234 gene sequence. Products were sequenced (ABI3500XL), and the sequences were aligned, edited (BioEdit), and analyzed (Blastn). Results: Of the 34 amplified samples, 21 were sequenced, namely Leishmania infantum (12), L. guyanensis (5), L. braziliensis (3), and Leishmania sp. (01). Conclusion: Given the diversity of circulating pathogens, elucidation of the role of the dog in the Leishmania spp. cycle in Amazonian villages is imperative to the surveillance of CL in the region. We present the first report in Brazil, confirmed by sequencing, of canine infection by L. guyanensis , a species highly resistant to treatment in humans, with the drug of first choice (Glucantime ® ).

Suggested Citation

  • Francisco J. A. Santos & Luciana C. S. Nascimento & Wellington B. Silva & Luciana P. Oliveira & Walter S. Santos & Délia C. F. Aguiar & Lourdes M. Garcez, 2020. "First Report of Canine Infection by Leishmania ( Viannia ) guyanensis in the Brazilian Amazon," IJERPH, MDPI, vol. 17(22), pages 1-9, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:22:p:8488-:d:445895
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    References listed on IDEAS

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    1. Rupert J Quinnell & Connor Carson & Richard Reithinger & Lourdes M Garcez & Orin Courtenay, 2013. "Evaluation of rK39 Rapid Diagnostic Tests for Canine Visceral Leishmaniasis: Longitudinal Study and Meta-Analysis," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 7(1), pages 1-11, January.
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    Cited by:

    1. Luciana P. Oliveira & Luciana C. S. Nascimento & Fabiola S. Santos & Jaqueline L. C. Takamatsu & Luiz R. P. Sanchez & Walter S. Santos & Lourdes M. Garcez, 2022. "First Report of an Asymptomatic Leishmania (Viannia) shawi Infection Using a Nasal Swab in Amazon, Brazil," IJERPH, MDPI, vol. 19(10), pages 1-10, May.

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