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Gestational Pesticide Exposure and Child Respiratory Health

Author

Listed:
  • Robyn Gilden

    (Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD 21201, USA)

  • Erika Friedmann

    (Office of Research and Scholarship, University of Maryland School of Nursing, Baltimore, MD 21201, USA)

  • Katie Holmes

    (Office of Research and Scholarship, University of Maryland School of Nursing, Baltimore, MD 21201, USA)

  • Kimberly Yolton

    (Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA)

  • Yingying Xu

    (Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA)

  • Bruce Lanphear

    (Department of Health Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada)

  • Aimin Chen

    (Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA)

  • Joseph Braun

    (Department of Epidemiology, Brown University, Providence, RI 02912, USA)

  • Adam Spanier

    (Department of Pediatrics, Division of General Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA)

Abstract

Background: Childhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase; PON1 ) may modify the effects of exposure. Methods: We analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (OP) and pyrethroid (3PBA) metabolite concentrations with child wheeze, forced expiratory volume in one second (FEV1) at ages 4 and 5 years, and wheeze trajectory patterns through age 8 years. Results: Among 367 singletons, the frequency of wheeze ranged from 10.6% to 24.1% at each measurement age. OP and 3PBA metabolite concentrations were not associated with wheeze at 8 years or from birth to 8 years, but there were three significant interactions: (1) maternal daily fruit and vegetable consumption (less than daily consumption and increasing 3PBA was associated with wheeze at age 8 years, OR = 1.40), (2) maternal PON1 - 108 allele (CT/TT genotypes and high DE was associated with wheeze at age 8 years, OR = 2.13, 2.74) and (3) PON1 192 alleles (QR/RR genotypes with higher diethylphosphate (DE) and dialkyl phosphate (DAP) were associated with wheeze at age 8 years, OR = 3.84). Pesticide metabolites were not consistently related to FEV1 or wheeze trajectory. Conclusions: Gestational OP and 3PBA metabolites were associated with child respiratory outcomes in participants with maternal dietary and genetic susceptibility.

Suggested Citation

  • Robyn Gilden & Erika Friedmann & Katie Holmes & Kimberly Yolton & Yingying Xu & Bruce Lanphear & Aimin Chen & Joseph Braun & Adam Spanier, 2020. "Gestational Pesticide Exposure and Child Respiratory Health," IJERPH, MDPI, vol. 17(19), pages 1-18, September.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:19:p:7165-:d:421958
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    References listed on IDEAS

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    1. Ming Ye & Jeremy Beach & Jonathan W. Martin & Ambikaipakan Senthilselvan, 2013. "Occupational Pesticide Exposures and Respiratory Health," IJERPH, MDPI, vol. 10(12), pages 1-30, November.
    2. Catherine L. Callahan & Manal Al-Batanony & Ahmed A. Ismail & Gaafar Abdel-Rasoul & Olfat Hendy & James R. Olson & Diane S. Rohlman & Matthew R. Bonner, 2014. "Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers," IJERPH, MDPI, vol. 11(12), pages 1-13, December.
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    Cited by:

    1. María Isabel Ventura-Miranda & Isabel María Fernández-Medina & Eulalia Guillén-Romera & Rocío Ortíz-Amo & María Dolores Ruíz-Fernández, 2022. "Effect of Gestational Pesticide Exposure on the Child’s Respiratory System: A Narrative Review," IJERPH, MDPI, vol. 19(22), pages 1-15, November.

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