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The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae

Author

Listed:
  • Guoying Wang

    (Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
    These authors contributed equally to this work and should be considered co-first authors.)

  • Guo Zhao

    (Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
    These authors contributed equally to this work and should be considered co-first authors.)

  • Xiaoyu Chao

    (Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China)

  • Longxiang Xie

    (Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China)

  • Hongju Wang

    (Institute of Biomedical Informatics, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China)

Abstract

Klebsiella pneumoniae is an important gram-negative opportunistic pathogen that causes a variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and liver abscesses. With the emergence of multidrug-resistant (MDR) and hypervirulent K. pneumoniae ( hvKP ) strains, the rapid spread of these clinical strains in geography is particularly worrying. However, the detailed mechanisms of virulence and antibiotic resistance in K. pneumoniae are still not very clear. Therefore, studying and elucidating the pathogenic mechanisms and drug resistance mechanism of K. pneumoniae infection are important parts of current medical research. In this paper, we systematically summarized the virulence, biofilm, and antibiotic tolerance mechanisms of K. pneumoniae , and explored the application of whole genome sequencing and global proteomics, which will provide new clues for clinical treatment of K. pneumoniae .

Suggested Citation

  • Guoying Wang & Guo Zhao & Xiaoyu Chao & Longxiang Xie & Hongju Wang, 2020. "The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae," IJERPH, MDPI, vol. 17(17), pages 1-17, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:17:p:6278-:d:405648
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    Cited by:

    1. Nikolett Orosz & Tünde Tóthné Tóth & Gyöngyi Vargáné Gyuró & Zsoltné Tibor Nábrádi & Klára Hegedűsné Sorosi & Zsuzsa Nagy & Éva Rigó & Ádám Kaposi & Gabriella Gömöri & Cornelia Melinda Adi Santoso & A, 2022. "Comparison of Length of Hospital Stay for Community-Acquired Infections Due to Enteric Pathogens, Influenza Viruses and Multidrug-Resistant Bacteria: A Cross-Sectional Study in Hungary," IJERPH, MDPI, vol. 19(23), pages 1-16, November.
    2. Wendi Cao & Yi Xu & Yicai Huang & Tianle Xu, 2023. "Isolation of Pathogenic Bacteria from Dairy Cow Mastitis and Correlation of Biofilm Formation and Drug Resistance of Klebsiella pneumoniae in Jiangsu, China," Agriculture, MDPI, vol. 13(10), pages 1-12, October.
    3. Małgorzata Timler & Wojciech Timler & Ariadna Bednarz & Łukasz Zakonnik & Remigiusz Kozłowski & Dariusz Timler & Michał Marczak, 2023. "Identification and Preliminary Hierarchisation of Selected Risk Factors for Carbapenemase-Producing Enterobacteriaceae (CPE) Colonisation: A Prospective Study," IJERPH, MDPI, vol. 20(3), pages 1-12, January.

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