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Medication Event Monitoring System for Infectious Tuberculosis Treatment in Morocco: A Retrospective Cohort Study

Author

Listed:
  • Seup Park

    (Global Care International, Seoul 08377, Korea
    These authors contributed equally.)

  • Ilham Sentissi

    (Chief Public Health Service and Epidemiological Surveillance, Moroccan League Against Tuberculosis (Ligue Marocaine de Lute Contre la Tuberculosis, LMCT), Rabat 10000, Morocco
    These authors contributed equally.)

  • Seung Jae Gil

    (Global Care International, Seoul 08377, Korea)

  • Won-Seok Park

    (Global Care International, Seoul 08377, Korea)

  • ByungKwon Oh

    (Global Care International, Seoul 08377, Korea)

  • Ah Reum Son

    (Global Care International, Seoul 08377, Korea)

  • Young Ju Kong

    (Global Care International, Seoul 08377, Korea)

  • Sol Park

    (Division of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan-City 15355, Korea)

  • Eunseong Paek

    (Global Care International, Seoul 08377, Korea)

  • Yong Joon Park

    (Global Care International, Seoul 08377, Korea)

  • Seung Heon Lee

    (Global Care International, Seoul 08377, Korea
    Division of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan-City 15355, Korea)

Abstract

Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group ( p = 0.7147), and the mean age and sex were not different between the two groups ( p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13–8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05–0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group ( p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.

Suggested Citation

  • Seup Park & Ilham Sentissi & Seung Jae Gil & Won-Seok Park & ByungKwon Oh & Ah Reum Son & Young Ju Kong & Sol Park & Eunseong Paek & Yong Joon Park & Seung Heon Lee, 2019. "Medication Event Monitoring System for Infectious Tuberculosis Treatment in Morocco: A Retrospective Cohort Study," IJERPH, MDPI, vol. 16(3), pages 1-9, January.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:3:p:412-:d:202345
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    References listed on IDEAS

    as
    1. Narges Alipanah & Leah Jarlsberg & Cecily Miller & Nguyen Nhat Linh & Dennis Falzon & Ernesto Jaramillo & Payam Nahid, 2018. "Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies," PLOS Medicine, Public Library of Science, vol. 15(7), pages 1-44, July.
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    Cited by:

    1. Seup Park & Narae Moon & Byungkwon Oh & Miyeon Park & Kilho Kang & Ilham Sentissi & Sung-Heui Bae, 2021. "Improving Treatment Adherence with Integrated Patient Management for TB Patients in Morocco," IJERPH, MDPI, vol. 18(19), pages 1-12, September.

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