IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i16p2840-d256005.html
   My bibliography  Save this article

Body Fat Mass and Risk of Cerebrovascular Lesions: The PRESENT (Prevention of Stroke and Dementia) Project

Author

Listed:
  • Im-Seok Koh

    (Department of Neurology, National medical center, Seoul 04564, Korea)

  • Yang-Ki Minn

    (Department of Neurology, Kangnam Sacred Hospital, Hallym University, Seoul 07441, Korea)

  • Seung-Han Suk

    (Department of Neurology, Wonkwang University, Sanbon Medical Center, Gunpo 15865, Korea)

Abstract

Obesity is known to increase the risk of stroke. It is unclear whether high absolute fat mass (FM) increases the risk of stroke independently. We studied the correlation between FM and silent brain infarction/white matter change (SI/WMC) using brain computed tomography. We selected subjects from the local government health promotion project. We randomly selected a target population that had never been diagnosed with stroke or dementia. FM was measured by bioelectrical impedance analysis (BIA). We divided the subjects into three groups according to the FM (gender-specific tertiles [GTx]). Seven hundred and twenty-two subjects (321 men) between 50 and 75 years of age were recruited. The overall odds ratio (OR) of SI/WMC was 2.23 (95% confidence interval (CI), 1.34–3.71; p = 0.002) times higher in the 37th to 100th percentiles (GT 3 ) than in the first to 32nd percentiles (GT 1 ). When men and women were separated, the OR of GT 3 was 1.35 (CI, 0.62–2.94; p = 0.45) in men and 3.2 (CI, 1.60–6.40; p = 0.001) in women. The findings were not found to be statistically significant after adjusting for the well-known stroke risk factors. When the subjects were divided into a high FM (HFMG, GT 3 ) and low FM group (LFMG, GT 1 + GT 2 ), the HFMG showed an increased OR of SI/WMC in women. Similar results were seen after adjusted (overall: OR, 1.38; CI, 0.85–2.25, p = 0.198; men: OR, 0.93; CI, 0.422–2.051; p = 0.86; women: OR, 2.02; CI, 1.06–3.86; p = 0.03). The findings suggest that high FM may be an independent risk factor for ischemic stroke among adults free from stroke and dementia, especially in women.

Suggested Citation

  • Im-Seok Koh & Yang-Ki Minn & Seung-Han Suk, 2019. "Body Fat Mass and Risk of Cerebrovascular Lesions: The PRESENT (Prevention of Stroke and Dementia) Project," IJERPH, MDPI, vol. 16(16), pages 1-8, August.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:16:p:2840-:d:256005
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/16/2840/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/16/2840/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jun Lv & Wei Chen & Dianjianyi Sun & Shengxu Li & Iona Y Millwood & Margaret Smith & Yu Guo & Zheng Bian & Canqing Yu & Huiyan Zhou & Yunlong Tan & Junshi Chen & Zhengming Chen & Liming Li & China Kad, 2015. "Gender-Specific Association between Tobacco Smoking and Central Obesity among 0.5 Million Chinese People: The China Kadoorie Biobank Study," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-15, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mengying Wang & Wenyong Li & Ren Zhou & Siyue Wang & Hongchen Zheng & Jin Jiang & Shengfeng Wang & Canqing Yu & Wenjing Gao & Jun Lv & Tao Wu & Weihua Cao & Yonghua Hu & Liming Li & John S. Ji, 2020. "The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People," IJERPH, MDPI, vol. 17(8), pages 1-11, April.
    2. Xinge Zhang & Yueqiao Wang & Jason S. Brinkley & Theresa M. Oniffrey & Rui Zhang & Guoxun Chen & Rui Li & Justin B. Moore, 2018. "Eating Frequency Is Not Associated with Obesity in Chinese Adults," IJERPH, MDPI, vol. 15(11), pages 1-10, November.
    3. Callison, Kevin & Schiman, Cuiping & Schiman, Jeffrey C., 2021. "Smoking cessation and weight gain: Evidence from China," Economics & Human Biology, Elsevier, vol. 43(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:16:p:2840-:d:256005. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.