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Association of lncRNA CCAT2 and CASC8 Gene Polymorphisms with Hepatocellular Carcinoma

Author

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  • Edie-Rosmin Wu

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of General Surgery, Department of Surgery, Lin Shin Hospital, Taichung 408, Taiwan
    These authors contributed equally to this work.)

  • Ming-Ju Hsieh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
    Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    These authors contributed equally to this work.)

  • Whei-Ling Chiang

    (School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan)

  • Kuan-Chun Hsueh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of General Surgery, Department of Surgery, Tungs’ Taichung MetroHarbor Hospital, Taichung 433, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Shih-Chi Su

    (Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung 204, Taiwan
    Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung 204, Taiwan)

Abstract

The worldwide incidence of hepatocellular carcinoma (HCC), the major histological type of primary liver cancer, is heterogeneous due to the variable prevalence of etiological factors, indicating a correlation of HCC risk with genetic variations among individuals. Among long non-coding RNAs (lncRNAs) located in the chromosome 8q24 loci and involved in the carcinogenesis are colon cancer associated transcript 2 ( CCAT2 ) and cancer susceptibility candidate 8 ( CASC8 ). In this study, the association of CCAT2 and CASC8 gene polymorphisms with the occurrence of HCC was explored between 397 HCC patients and 1195 controls. We found that carriers of rs6983267 GG in CCAT2 were more susceptible to HCC, with the odds ratio (OR) and adjusted odds ratio (AOR) being 1.532 (95% CI, 1.103–2.129; p = 0.011) and 1.627 (95% CI, 1.120–2.265; p = 0.033), respectively. Moreover, for patients stratified by age (under 65), gender (male only), or status of drinking (habitual drinkers), a protective effect of CASC8 rs3843549 on presenting high Child–Pugh scores, metastatic vascular invasion, or large-size tumors was observed in a dominant model. Collectively, our data reveal association of CCAT2 and CASC8 gene polymorphisms with the occurrence and progression of HCC.

Suggested Citation

  • Edie-Rosmin Wu & Ming-Ju Hsieh & Whei-Ling Chiang & Kuan-Chun Hsueh & Shun-Fa Yang & Shih-Chi Su, 2019. "Association of lncRNA CCAT2 and CASC8 Gene Polymorphisms with Hepatocellular Carcinoma," IJERPH, MDPI, vol. 16(16), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:16:p:2833-:d:255844
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    References listed on IDEAS

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    1. Sarah Djebali & Carrie A. Davis & Angelika Merkel & Alex Dobin & Timo Lassmann & Ali Mortazavi & Andrea Tanzer & Julien Lagarde & Wei Lin & Felix Schlesinger & Chenghai Xue & Georgi K. Marinov & Jaina, 2012. "Landscape of transcription in human cells," Nature, Nature, vol. 489(7414), pages 101-108, September.
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