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Endocrine Disruptors Leading to Obesity and Related Diseases

Author

Listed:
  • Demetrios Petrakis

    (Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece
    These authors contributed equally to this work.)

  • Loukia Vassilopoulou

    (Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece
    These authors contributed equally to this work.)

  • Charalampos Mamoulakis

    (Department of Urology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Crete, Greece
    These authors contributed equally to this work.)

  • Christos Psycharakis

    (Department of Obstetrics and Gynecology, Venizeleio—Pananio General Hospital of Heraklion, 71409 Heraklion, Crete, Greece)

  • Aliki Anifantaki

    (Crete Fertility Center, 56, Arch. Makariou & Sof. Venizelou Str., 71202 Heraklion, Crete, Greece)

  • Stavros Sifakis

    (Mitera Hospital, 71409 Heraklion, Crete, Greece)

  • Anca Oana Docea

    (Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy, Petru Rares, 200349 Craiova, Romania)

  • John Tsiaoussis

    (Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece)

  • Antonios Makrigiannakis

    (Department of Obstetrics and Gynecology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece)

  • Aristides M. Tsatsakis

    (Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece)

Abstract

The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.

Suggested Citation

  • Demetrios Petrakis & Loukia Vassilopoulou & Charalampos Mamoulakis & Christos Psycharakis & Aliki Anifantaki & Stavros Sifakis & Anca Oana Docea & John Tsiaoussis & Antonios Makrigiannakis & Aristides, 2017. "Endocrine Disruptors Leading to Obesity and Related Diseases," IJERPH, MDPI, vol. 14(10), pages 1-18, October.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:10:p:1282-:d:116277
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    References listed on IDEAS

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    Cited by:

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    2. Saira Amir & Syed Tahir Abbas Shah & Charalampos Mamoulakis & Anca Oana Docea & Olga-Ioanna Kalantzi & Athanasios Zachariou & Daniela Calina & Felix Carvalho & Nikolaos Sofikitis & Antonios Makrigiann, 2021. "Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review," IJERPH, MDPI, vol. 18(4), pages 1-20, February.
    3. Monica Lopes-Ferreira & Adolfo Luis Almeida Maleski & Leticia Balan-Lima & Jefferson Thiago Gonçalves Bernardo & Lucas Marques Hipolito & Ana Carolina Seni-Silva & Joao Batista-Filho & Maria Alice Pim, 2022. "Impact of Pesticides on Human Health in the Last Six Years in Brazil," IJERPH, MDPI, vol. 19(6), pages 1-19, March.
    4. Jose L. García-Soidán & Raquel Leirós-Rodríguez & Vicente Romo-Pérez & Víctor Arufe-Giráldez, 2020. "Evolution of the Habits of Physical Activity and Television Viewing in Spanish Children and Pre-Adolescents between 1997 and 2017," IJERPH, MDPI, vol. 17(18), pages 1-13, September.
    5. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.

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