Comprehensive Exploitation of Uncaria rhynchophylla : Cultivation Optimization, Whole-Plant Utilization, and By-Product Valorization Toward an Ecological Circular Economy

Uncaria rhynchophylla is an important medicinal plant widely used for treating neurological and cardiovascular diseases. However, current utilization primarily focuses on its hooked stems ( Uncariae Ramulus cum Uncis ), while its by-products remain underutilized. A systematic understanding of its cultivation and whole-plant utilization is lacking, limiting its industrial and ecological potential. We comprehensively evaluated the cultivation, processing, by-product utilization, and ecological value of U. rhynchophylla within an industrial crop framework. This review synthesizes recent advances in agronomic practices, phytochemical composition, environmental influences, and product development strategies by integrating findings from experimental and applied studies. The hooked stems are rich in alkaloids such as rhynchophylline, while other plant parts contain valuable active compounds suitable for bio-based products, including functional foods and medicinal materials. Environmental factors (light, soil, altitude) and cultivation strategies significantly influence yield and active compound accumulation. Whole-plant utilization and by-product valorization can enhance resource-use efficiency and economic returns. U. rhynchophylla has significant potential as an industrial medicinal crop. Integrating optimized cultivation, processing technologies, and by-product utilization strategies supports sustainable production and rural development. However, limitations include standardization and limited large-scale validation. Future research should focus on mechanistic studies, industrial-scale processing, and development of high-value products to promote a circular bioeconomy.