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The Effect of Dietary Humic Substances on Cellular Immunity and Blood Characteristics in Piglets

Author

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  • Lukáš Bujňák

    (Department of Animal Nutrition and Husbandry, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

  • Alena Hreško Šamudovská

    (Department of Animal Nutrition and Husbandry, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

  • Dagmar Mudroňová

    (Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

  • Pavel Naď

    (Department of Animal Nutrition and Husbandry, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

  • Slavomír Marcinčák

    (Department of Food Hygiene, Technology and Safety, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

  • Iveta Maskaľová

    (Department of Animal Nutrition and Husbandry, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

  • Michaela Harčárová

    (Department of Animal Nutrition and Husbandry, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

  • Viera Karaffová

    (Department of Morphological Disciplines, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

  • Martin Bartkovský

    (Department of Food Hygiene, Technology and Safety, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia)

Abstract

This study’s objective was to determine the impact of dietary humic substances on immune response and blood profiles in piglets. A total of 24 crossbred piglets (Slovakian White × Landrace; 35 days old; average body weight of 11.67 kg) were allotted to two dietary groups with (experimental; 5 g·kg −1 ) or without (control; 0 g·kg −1 ) natural humic substances supplementation. In this study, we observed a significant increase of the proportion of CD4+CD8- lymphocytes ( p < 0.001) in the experimental group. The results also showed a tendency for an increase of the phagocytic activity and the engulfing capacity of phagocytes and the numbers of the other monitored lymphocyte subpopulations (CD3+, CD21+, CD4-D8+, CD4+CD8+, CD4+CD25+) in piglets in the experimental group compared to the control group. Supplementation of humic substances increased serum alkaline phosphatase compared to the control group ( p < 0.05). Other monitored blood parameters were not significantly affected by dietary treatment. It concluded that inclusion of humic substances in the diet of piglets could have a stimulating effect on cellular immunity, without a negative effect on haematological and biochemical parameters.

Suggested Citation

  • Lukáš Bujňák & Alena Hreško Šamudovská & Dagmar Mudroňová & Pavel Naď & Slavomír Marcinčák & Iveta Maskaľová & Michaela Harčárová & Viera Karaffová & Martin Bartkovský, 2023. "The Effect of Dietary Humic Substances on Cellular Immunity and Blood Characteristics in Piglets," Agriculture, MDPI, vol. 13(3), pages 1-12, March.
    • Handle: RePEc:gam:jagris:v:13:y:2023:i:3:p:636-:d:1090759
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    References listed on IDEAS

    as
    1. Dagmar Mudroňová & Viera Karaffová & Boris Semjon & Pavel Naď & Jana Koščová & Martin Bartkovský & Andrej Makiš & Lukáš Bujňák & Jozef Nagy & Jana Mojžišová & Slavomír Marcinčák, 2021. "Effects of Dietary Supplementation of Humic Substances on Production Parameters, Immune Status and Gut Microbiota of Laying Hens," Agriculture, MDPI, vol. 11(8), pages 1-14, August.
    2. Branislav Gálik & Cyril Hrnčár & Martin Gašparovič & Michal Rolinec & Ondrej Hanušovský & Miroslav Juráček & Milan Šimko & Luboš Zábranský & Anton Kovacik, 2023. "The Effect of Humic Substances on the Meat Quality in the Fattening of Farm Pheasants ( Phasianus colchicus )," Agriculture, MDPI, vol. 13(2), pages 1-10, January.
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