IDEAS home Printed from https://ideas.repec.org/a/gam/jagris/v13y2023i1p143-d1026375.html
   My bibliography  Save this article

New Insights on Coding Mutations and mRNA Levels of Candidate Genes Associated with Diarrhea Susceptibility in Baladi Goat

Author

Listed:
  • Mona Al-Sharif

    (Department of Biology, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia)

  • Ahmed Ateya

    (Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt)

Abstract

The purpose of this investigation was to examine mutations and mRNA levels of potential genes linked to diarrhea susceptibility in order to assess the health status of diarrheic kids of Baladi goats. One hundred female Baladi kids (35 diarrheic and 65 apparently healthy) were used. PCR-DNA sequencing was conducted for TMED1 , CALR , FBXW9 , HS6ST3 , SMURF1 , KPNA7 , FBXL2 , PIN1 , S1PR5 , ICAM1 , EDN1 , MAPK11 , CSF1R , LRRK1 , and CFH markers revealed nucleotide sequence variants in the frequency of distribution of all detected SNPs ( p ˂ 0.05) between healthy and affected kids. Chi-square analysis showed a significant difference between resistant and affected animals. Gene expression profile revealed that TMED1 , CALR , FBXW9 , HS6ST3 , SMURF1 , KPNA7 , FBXL2 , PIN1 , S1PR5 , ICAM1 , EDN1 , MAPK11 , CSF1R and LRRK1 were significantly up-regulated in diarrheic kids than resistant ones. Meanwhile, CFH gene elicited an opposite trend. On the mRNA levels of the examined indicators, there was a substantial interaction between the type of gene and diarrhea resistance/susceptibility. The findings could support the importance of nucleotide variations and the expression pattern of the examined genes as biomarkers for diarrhea resistance/susceptibility and offer a useful management strategy for Baladi goats.

Suggested Citation

  • Mona Al-Sharif & Ahmed Ateya, 2023. "New Insights on Coding Mutations and mRNA Levels of Candidate Genes Associated with Diarrhea Susceptibility in Baladi Goat," Agriculture, MDPI, vol. 13(1), pages 1-15, January.
    • Handle: RePEc:gam:jagris:v:13:y:2023:i:1:p:143-:d:1026375
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2077-0472/13/1/143/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2077-0472/13/1/143/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Haitao Zhu & Peter Kavsak & Shirin Abdollah & Jeffrey L. Wrana & Gerald H. Thomsen, 1999. "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation," Nature, Nature, vol. 400(6745), pages 687-693, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yesheng Fu & Lei Li & Xin Zhang & Zhikang Deng & Ying Wu & Wenzhe Chen & Yuchen Liu & Shan He & Jian Wang & Yuping Xie & Zhiwei Tu & Yadi Lyu & Yange Wei & Shujie Wang & Chun-Ping Cui & Cui Hua Liu & , 2024. "Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jagris:v:13:y:2023:i:1:p:143-:d:1026375. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.