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Metabolome Analysis Reveals Potential Mechanisms of Mannan Oligosaccharides to Improve Health, Growth Performance, and Fatty Acid Deposition in Hu Lambs

Author

Listed:
  • Ting Liu

    (College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China)

  • Fadi Li

    (State Key Laboratory of Grassland Agro-Ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730020, China
    Engineering Laboratory of Mutton Sheep Breeding and Reproduction Biotechnology in Gansu Province, Minqin 733300, China)

  • Jianfeng Xu

    (College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China)

  • Jing Wang

    (College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China)

  • Zhenfeng Shen

    (College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China)

  • Fan Zhang

    (College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China)

  • Jiaqi Wang

    (College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China)

  • Chen Zheng

    (College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China)

Abstract

The effect of mannan oligosaccharides (MOS) on health, growth performance, fatty acids deposition, serum, and urine metabolites, as well as the correlation between differential metabolites and other indexes, were investigated in Hu lambs. In total, 30 seven-day-old Hu male lambs were fed a milk replacer with or without 0.2% MOS (15 lambs in each). The lambs were placed on this diet until they were 28 days old. MOS significantly increased the apparent digestibility of organic matter (OM), crude protein (CP), ether extract (EE), calcium (Ca) and phosphorus (P), and unsaturated fatty acid (UFA) proportion, and decreased the diarrhea rate and saturated fatty acid (SFA) proportion in lambs ( p < 0.05). MOS upregulated 20 metabolites in serum and 1 in urine and downregulated 11 metabolites in serum and 2 in urine ( p < 0.05). Most of these metabolites comprised glycerophosphoethanolamines and glycerophosphocholines, which are significantly correlated with nutrient digestibility and fatty acid composition ( p < 0.05). Overall, our results suggest that MOS benefited the health, nutrient utilization, and fatty acid profiles in Hu lambs via glycerolipid and glycerophospholipid metabolism pathways.

Suggested Citation

  • Ting Liu & Fadi Li & Jianfeng Xu & Jing Wang & Zhenfeng Shen & Fan Zhang & Jiaqi Wang & Chen Zheng, 2022. "Metabolome Analysis Reveals Potential Mechanisms of Mannan Oligosaccharides to Improve Health, Growth Performance, and Fatty Acid Deposition in Hu Lambs," Agriculture, MDPI, vol. 12(9), pages 1-19, August.
    • Handle: RePEc:gam:jagris:v:12:y:2022:i:9:p:1327-:d:900143
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