IDEAS home Printed from https://ideas.repec.org/a/gam/jagris/v12y2022i7p947-d852618.html

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

Author

Listed:
  • Qinyue Lu

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China
    These authors contributed equally to this work.)

  • Weicheng Zong

    (College of Veterinary Medcine, Yangzhou University, Yangzhou 225009, China
    These authors contributed equally to this work.)

  • Mingyixing Zhang

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China)

  • Zhi Chen

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China)

  • Zhangping Yang

    (College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
    Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China)

Abstract

Beta-oxidation(β-oxidation) is an important metabolic process involving multiple steps by which fatty acid molecules are broken down to produce energy. The very long-chain fatty acids (VLCFAs), a type of fatty acid (FA), are usually highly toxic when free in vivo, and their oxidative metabolism depends on the peroxisomal β-oxidation. For a long time, although β-oxidation takes place in both mitochondria and peroxisomes, most studies have been keen to explore the mechanism of β-oxidation in mitochondria while ignoring the importance of peroxisomal β-oxidation. However, current studies indicate that it is hard to provide effective treatment for diseases caused by the disorder of peroxisomal β-oxidation, such as X-ALD, SCOX deficiency, and D-BP deficiency; thus, actions should be taken to solve this problem. Based on existing research results, this review will summarize the importance of peroxisomal β-oxidation and help further learning.

Suggested Citation

  • Qinyue Lu & Weicheng Zong & Mingyixing Zhang & Zhi Chen & Zhangping Yang, 2022. "The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation," Agriculture, MDPI, vol. 12(7), pages 1-21, June.
    • Handle: RePEc:gam:jagris:v:12:y:2022:i:7:p:947-:d:852618
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2077-0472/12/7/947/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2077-0472/12/7/947/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Ayumu Sugiura & Sevan Mattie & Julien Prudent & Heidi M. McBride, 2017. "Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes," Nature, Nature, vol. 542(7640), pages 251-254, February.
    2. Jinuk Kong & Yul Ji & Yong Geun Jeon & Ji Seul Han & Kyung Hee Han & Jung Hyun Lee & Gung Lee & Hagoon Jang & Sung Sik Choe & Myriam Baes & Jae Bum Kim, 2020. "Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chi Yao & Yuwei Xu & Jianpu Tang & Pin Hu & Hedong Qi & Dayong Yang, 2022. "Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Marco Scalabrin & Eloisa Turco & Ilaria Davigo & Riccardo Filadi & Leonardo Nogara & Gaia Gherardi & Lucia Barazzuol & Andrea Armani & Giulia Trani & Samuele Negro & Anais Franco-Romero & Yorrick Jasp, 2025. "Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction," Nature Communications, Nature, vol. 16(1), pages 1-24, December.
    3. Giovanna Coceano & Jonatan Alvelid & Martina Damenti & Gabriella Ferretti & Johannes Mueller & Joanna Rorbach & Ilaria Testa, 2026. "Quantitative optical nanoscopy of mitochondrial-derived vesicles in neurons classifies pre-peroxisomal and clearing organelles," Nature Communications, Nature, vol. 17(1), pages 1-19, December.

    More about this item

    Keywords

    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jagris:v:12:y:2022:i:7:p:947-:d:852618. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager The email address of this maintainer does not seem to be valid anymore. Please ask MDPI Indexing Manager to update the entry or send us the correct address (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.