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The Role of Insect Cytochrome P450s in Mediating Insecticide Resistance

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  • Min Ye

    (State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    International Joint Research Laboratory of Ecological Pest Control, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Bidhan Nayak

    (School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China)

  • Lei Xiong

    (State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    International Joint Research Laboratory of Ecological Pest Control, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Chao Xie

    (State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    International Joint Research Laboratory of Ecological Pest Control, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Yi Dong

    (State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    International Joint Research Laboratory of Ecological Pest Control, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Minsheng You

    (State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    International Joint Research Laboratory of Ecological Pest Control, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Zhiguang Yuchi

    (School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China)

  • Shijun You

    (State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    International Joint Research Laboratory of Ecological Pest Control, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

Abstract

In many organisms, cytochrome P450 enzymes are the primary detoxifying enzymes. Enhanced P450 activity can be mediated by the emergence of new genes, increased transcription due to mutations in the promoter regions, changes in enzyme structures and functions due to mutations in protein-coding regions, or changes in post-translational modifications; all of these changes are subject to insecticide selection pressure. Multiple signalling pathways and key effector molecules are involved in the regulation of insect P450s. Increased P450 activity is a key mechanism inducing insect resistance. Hence, downregulation of selected P450s is a promising strategy to overcome this resistance. Insect P450 inhibitors that act as insecticide synergists, RNA interference to induce P450 gene silencing, and the use of transgenic insects and crops are examples of strategies utilized to overcome resistance. This article reviews the latest advances in studies related to insect P450s-mediated agrochemical resistance, with focuses on the regulatory mechanisms and associated pest management strategies. Future investigations on the comprehensive regulatory pathways of P450-mediated detoxification, identification of key effectors, and downregulation strategies for P450s will ecologically, economically, and practically improve pest management.

Suggested Citation

  • Min Ye & Bidhan Nayak & Lei Xiong & Chao Xie & Yi Dong & Minsheng You & Zhiguang Yuchi & Shijun You, 2022. "The Role of Insect Cytochrome P450s in Mediating Insecticide Resistance," Agriculture, MDPI, vol. 12(1), pages 1-18, January.
    • Handle: RePEc:gam:jagris:v:12:y:2022:i:1:p:53-:d:716200
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    Citations

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    Cited by:

    1. Meiyuan Ji & Marilou Vandenhole & Berdien Beer & Sander Rouck & Ernesto Villacis-Perez & René Feyereisen & Richard M. Clark & Thomas Leeuwen, 2023. "A nuclear receptor HR96-related gene underlies large trans-driven differences in detoxification gene expression in a generalist herbivore," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Sam M. Espinoza Vidaurre & Norma C. Velásquez Rodríguez & Renza L. Gambetta Quelopana & Ana N. Martinez Valdivia & Ernesto A. Leo Rossi & Kevin Mario Laura De La Cruz, 2023. "Understanding Factors That Influence Pest Risk in Olive Production," Sustainability, MDPI, vol. 15(23), pages 1-19, November.
    3. Xiao Ran & Hadiatullah Hadiatullah & Zhiguang Yuchi & Xin Yang & Xun Zhu, 2023. "Sustainable Use of Pesticides," Agriculture, MDPI, vol. 13(7), pages 1-3, July.

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