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Synergistic Antinociceptive, Anti-inflammatory Interaction between Vitamin B12 and Ketorolac in Long Evans Rats

Author

Listed:
  • Md. Mizanur Rahman
  • Noorzahan Begum
  • Mahadi Abdur Rouf
  • Shahriar Masood

Abstract

In certain painful disorders, B12 vitamins have been documented to be clinically useful alone or paired with non-steroidal anti-inflammatory drugs (NSAIDs). However, it has not been identified to equate these effects with related effects of ketorolac tromethamine (KT) and their combination. To test and compare the effects of vitamin B12 on pain with those of the combination of vitamin B12 with KT in rat models. This experimental research was performed at the Department of Physiology, BSMMU. The control (A, A1 with 5 ml/kg normal saline) and experimental (B1, B1a with 15 mg/kg B12; B2, B2a with 10 mg/kg KT; B3, B3a with B12+KT) groups of 5 rats in each group were divided into 40 (forty) long Evans rats (215±35 gm) of either sex. Both medications and vitamins were administered intraperitoneally in a single dose just one hour prior to the writhing and paw edema test caused by formalin. The statistical study was carried out by ANOVA, followed by the post-hoc Bonferroni test. In the interpretation of outcomes, p≤0.05 was regarded as significant. B12 lowered only the writhing count and KT lowered both writhing appearance latency time and writhing count significantly (p≤0.001) in the writhing test. However, the combination of B12 and KT significantly (p≤0.001) lowered both the study variables in the writhing test. In addition, KT lowered edema volume significantly (p≤0.01) in the paw edema test. The combination of B12 and KT, on the other hand, substantially (p≤0.001) decreased the amount of edema in the paw edema test. It can be concluded that vitamin B12 has analgesic and anti-inflammatory effects, and that the combination of B12 with KT is more effective than when administered individually.

Suggested Citation

  • Md. Mizanur Rahman & Noorzahan Begum & Mahadi Abdur Rouf & Shahriar Masood, 2021. "Synergistic Antinociceptive, Anti-inflammatory Interaction between Vitamin B12 and Ketorolac in Long Evans Rats," European Journal of Clinical Medicine, European Open Science, vol. 2(3), pages 105-110, June.
    • Handle: RePEc:epw:clinic:v:2:y:2021:i:3:id:12094
    DOI: 10.24018/clinicmed.2021.2.3.94
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    References listed on IDEAS

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    1. David Julius & Allan I. Basbaum, 2001. "Molecular mechanisms of nociception," Nature, Nature, vol. 413(6852), pages 203-210, September.
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    JEL classification:

    • B12 - Schools of Economic Thought and Methodology - - History of Economic Thought through 1925 - - - Classical (includes Adam Smith)

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