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A Bartlett type correction for Wald test in Cox regression model

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  • Li, Xiao
  • Wu, Yaohua
  • Tu, Dongsheng

Abstract

In clinical trials with time to an event endpoint, the Wald test in a Cox regression model may be used to assess the difference between two treatments. In this paper, a Bartlett type correction to the Wald test is derived and applied to the analysis of data from a clinical trial on actuate myelogenous leukemia (AML). Monte Carlo simulations are also performed to assess the actual type I error and power of the proposed Bartlett corrected test.

Suggested Citation

  • Li, Xiao & Wu, Yaohua & Tu, Dongsheng, 2008. "A Bartlett type correction for Wald test in Cox regression model," Statistics & Probability Letters, Elsevier, vol. 78(16), pages 2614-2622, November.
    • Handle: RePEc:eee:stapro:v:78:y:2008:i:16:p:2614-2622
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    Cited by:

    1. Kakizawa, Yoshihide, 2012. "Improved chi-squared tests for a composite hypothesis," Journal of Multivariate Analysis, Elsevier, vol. 107(C), pages 141-161.

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