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Twisting, supercoiling and stretching in protein bound DNA

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  • Lam, Pui-Man
  • Zhen, Yi

Abstract

We have calculated theoretical results for the torque and slope of the twisted DNA, with various proteins bound on it, using the Neukirch–Marko model, in the regime where plectonemes exist. We found that the torque in the protein bound DNA decreases compared to that in the bare DNA. This is caused by the decrease in the free energy g(f), and hence the smaller persistence lengths, in the case of protein bound DNA. We hope our results will encourage experimental investigations of supercoiling in protein bound DNA, which can provide further tests of the Neukirch–Marko model.

Suggested Citation

  • Lam, Pui-Man & Zhen, Yi, 2018. "Twisting, supercoiling and stretching in protein bound DNA," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 496(C), pages 200-208.
    • Handle: RePEc:eee:phsmap:v:496:y:2018:i:c:p:200-208
    DOI: 10.1016/j.physa.2017.12.143
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    Cited by:

    1. Min, Seungsik & Shin, Ki-Hong & Baek, Woonhak & Kim, Kyungsik & You, Cheol-Hwan & Lee, Dong-In & Yum, Seong Soo & Kim, Wonheung & Chang, Ki-Ho, 2020. "Dynamical behavior of combined detrended cross-correlation analysis methods in random walks and Lévy flights," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 539(C).

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