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Information propagation from IP3 to target protein: A combined model for encoding and decoding of Ca2+ signal

Author

Listed:
  • Zhao, Qi
  • Yi, Ming
  • Xia, Kelin
  • Zhan, Meng

Abstract

It is well known that information is encoded in the frequency or amplitude of Ca2+ signal and then decoded by target protein. However, few models considered both the encoding and decoding procedures of Ca2+ signal. In this work, a minimal Li–Rinzel model is coupled with a phosphorylation–dephosphorylation cycle model, which is used to investigate information transmissions from inositol 1,4,5-trisphosphate (IP3) to target proteins and their relations. We found that the mean target protein activity increases with the IP3 concentration, and at a low level of stimulation, the target protein can be more efficiently activated by an oscillatory signal than a constant signal of the same average calcium if Ca2+ acts cooperatively on the kinase. The internal noise resulting from the finite system size is also taken into account in the combined model.

Suggested Citation

  • Zhao, Qi & Yi, Ming & Xia, Kelin & Zhan, Meng, 2009. "Information propagation from IP3 to target protein: A combined model for encoding and decoding of Ca2+ signal," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 388(19), pages 4105-4114.
    • Handle: RePEc:eee:phsmap:v:388:y:2009:i:19:p:4105-4114
    DOI: 10.1016/j.physa.2009.06.033
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