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Thermo-kinetic model for Prion diseases

Author

Listed:
  • Galdino, M.L
  • de Albuquerque, S.S
  • Ferreira, A.S
  • Cressoni, J.C
  • dos Santos, R.J.V

Abstract

A mean field theory of the auto catalytic Prions conversion reaction is developed under a conservation law for Prions density. These reactions take place in the brain where a normally folded Prion protein (PrPc) is converted into a misfolded, more stable, form (PrPSc). The results reproduce most of the known facts observed in Prion diseases such as: very long incubation time, rapid death after the first symptoms manifestation, dependence of the incubation and death times on the concentration of the initial contamination dose and the existence of a minimum contamination dose for the detection of the disease. Results of computing simulations are also presented.

Suggested Citation

  • Galdino, M.L & de Albuquerque, S.S & Ferreira, A.S & Cressoni, J.C & dos Santos, R.J.V, 2001. "Thermo-kinetic model for Prion diseases," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 295(1), pages 58-63.
    • Handle: RePEc:eee:phsmap:v:295:y:2001:i:1:p:58-63
    DOI: 10.1016/S0378-4371(01)00052-8
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    Keywords

    Prion diseases;

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