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Statistically significant strings are related to regulatory elements in the promoter regions of Saccharomyces cerevisiae

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  • Hu, Rui
  • Wang, Bin

Abstract

Finding out statistically significant words in DNA and protein sequences forms the basis for many genetic studies. By applying the maximal entropy principle, we give one systematic way to study the nonrandom occurrence of words in DNA or protein sequences. Through comparison with experimental results, it was shown that patterns of regulatory binding sites in Saccharomyces cerevisiae (yeast) genomes tend to occur significantly in the promoter regions. We studied two correlated gene families of yeast. The method successfully extracts the binding sites verified by experiments in each family. Many putative regulatory sites in the upstream regions are proposed. The study also suggested that some regulatory sites are active in both directions, while others show directional preference.

Suggested Citation

  • Hu, Rui & Wang, Bin, 2001. "Statistically significant strings are related to regulatory elements in the promoter regions of Saccharomyces cerevisiae," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 290(3), pages 464-474.
    • Handle: RePEc:eee:phsmap:v:290:y:2001:i:3:p:464-474
    DOI: 10.1016/S0378-4371(00)00488-X
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