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Complexation of DNA with cationic surfactant

Author

Listed:
  • Kuhn, Paulo S.
  • Barbosa, Marcia C.
  • Levin, Yan

Abstract

Transfection of an anionic polynucleotide through a negatively charged membrane is an important problem in genetic engineering. The direct association of cationic surfactant to DNA decreases the effective negative charge of the nucleic acid, allowing the DNA-surfactant complex to approach a negatively charged membrane. The paper develops a theory for solutions composed of polyelectrolyte, salt, and ionic surfactant. The theoretical predictions are compared with the experimental measurements.

Suggested Citation

  • Kuhn, Paulo S. & Barbosa, Marcia C. & Levin, Yan, 1999. "Complexation of DNA with cationic surfactant," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 269(2), pages 278-284.
    • Handle: RePEc:eee:phsmap:v:269:y:1999:i:2:p:278-284
    DOI: 10.1016/S0378-4371(99)00184-3
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