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Spatio-temporal dynamics of networks of heart cells in culture

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  • Cohen, Netta
  • Soen, Yoav
  • Braun, Erez

Abstract

Spontaneous activity of cultured rat ventricular heart cells is studied as a function of cell density and ambient temperature. Three complementary methods are used: calcium fluorescence microscopy (monitoring intracellular free Ca2+ concentrations), real-time motion detection and electrophysiology. Statistical features of beating activity in single cells, small groups of cells and large monolayered networks are characterized and compared. At relatively high temperatures, a gradual transition from stochastic activity at the level of a single cell to regular synchronized beating in large, dense networks is found. Lowering the temperature results in a gradual loss of synchronization and the emergence of spatio-temporal dynamics, expressed by bursts of activity and contractions on many length and time scales.

Suggested Citation

  • Cohen, Netta & Soen, Yoav & Braun, Erez, 1998. "Spatio-temporal dynamics of networks of heart cells in culture," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 249(1), pages 600-604.
    • Handle: RePEc:eee:phsmap:v:249:y:1998:i:1:p:600-604
    DOI: 10.1016/S0378-4371(97)00521-9
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