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Spectrum of relaxation time scales for metastable RNA folding

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  • Fernández, Ariel

Abstract

We investigate the universal (length-independent) behaviour in time of the two-base-pair correlation, ΔQ, in the folding of a random uncorrelated RNA chain. As a starting point, we provide evidence supporting the existence of a relaxation time scale with arate of divergence identical to the nonergodic relaxation time scale for spin glasses, as the thermodynamic limit is approached. The analysis is carried out making use of a Monte Carlo simulation which computes nonequilibrium refolding events occuring in a random uncorrelated primary sequence as it is formed by sequential incorporation of nucleotides. Our results on the universal behavior of ΔQ reveal the existence of a whole spectrum of relaxation time scales for folded states, each of these time scales diverging in the thermodynamic limit.

Suggested Citation

  • Fernández, Ariel, 1990. "Spectrum of relaxation time scales for metastable RNA folding," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 165(3), pages 352-360.
    • Handle: RePEc:eee:phsmap:v:165:y:1990:i:3:p:352-360
    DOI: 10.1016/0378-4371(90)90004-C
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