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Chemical triggering and hysteresis

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  • Schiffmann, Yoram

Abstract

Two-dimensional chemical systems are privileged. They allow for characteristics analogous to those found for first-order phase transitions, namely for discontinuous behaviour and hysteresis. This situation is demonstrated on a simple non-trivial model. The results demonstrate the advantage for biochemical reactions to occur in a fluid membrane. Bistability and rapid transition between a basal state and a more (or less) active state are secured for all chemical mechanisms. The failure of ligand-induced redistribution in the membrane, e.g. due to improper membrane fluidity or to dissociation of intrinsic proteins from the membrane into the solution, may lead to pathology and breakdown of homeostasis. Dose-response curves are derived from bifurcation diagrams and not from conformational change and cooperativity as usual, since it is suggested that the fundamental reason for the change in biochemical activity is the change of pattern in the membrane.

Suggested Citation

  • Schiffmann, Yoram, 1982. "Chemical triggering and hysteresis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 114(1), pages 74-83.
    • Handle: RePEc:eee:phsmap:v:114:y:1982:i:1:p:74-83
    DOI: 10.1016/0378-4371(82)90263-1
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