IDEAS home Printed from https://ideas.repec.org/a/eee/matcom/v79y2009i7p2091-2105.html
   My bibliography  Save this article

Distributions of the potential and electric field of an electrode elliptic array used in tumor electrotherapy: Analytical and numerical solutions

Author

Listed:
  • Aguilera, Andrés Ramírez
  • Cabrales, Luis Enrique Bergues
  • Ciria, Héctor Manuel Camué
  • Pérez, Yudelmis Soler
  • Oria, Eduardo Roca
  • Brooks, Soraida Acosta
  • González, Tamara Rubio

Abstract

To estimate the potential and electric field generated by any electrode array is very useful in effective tumor destruction. At present, an electrode array that takes into account the ellipsoidal geometry of the solid tumors has not been proposed. We present both analytical and numerical solutions for the potential and electric field in a solid tumor established by an electrode array with elliptic shape which may be used in vitro, in vivo and in clinical studies for cancer treatment with electrotherapy. These analytical and numerical solutions are obtained using multipole expansion and the finite difference method. Distributions of potential and electric field magnitudes are computed in function of the eccentricity of an elliptical array and compared with those obtained with a circular array of electrode. Maximum difference and Root Means Square Error are used to compare the distributions of the potential and electric field in leading-order and first-order correction and between the analytical and numerical solutions. The results show a good agreement between these distributions in both orders and the analytical and numerical solutions. It was concluded that the mathematical approach presented in this study is a tool for a rapid design of electrode elliptical arrays in order to induce the maximum destruction of the tumor. Moreover, it is shown that, for all values of eccentricity, there is a good correspondence between the distributions of the potential and the electric field for leading-order and first-order correction and for both the analytical and numerical solutions.

Suggested Citation

  • Aguilera, Andrés Ramírez & Cabrales, Luis Enrique Bergues & Ciria, Héctor Manuel Camué & Pérez, Yudelmis Soler & Oria, Eduardo Roca & Brooks, Soraida Acosta & González, Tamara Rubio, 2009. "Distributions of the potential and electric field of an electrode elliptic array used in tumor electrotherapy: Analytical and numerical solutions," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 79(7), pages 2091-2105.
    • Handle: RePEc:eee:matcom:v:79:y:2009:i:7:p:2091-2105
    DOI: 10.1016/j.matcom.2008.11.011
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0378475408003777
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.matcom.2008.11.011?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Cabrales, Luis Enrique Bergues & Aguilera, Andrés Ramírez & Jiménez, Rolando Placeres & Jarque, Manuel Verdecia & Ciria, Héctor Manuel Camué & Reyes, Juan Bory & Mateus, Miguel Angel O’Farril & Palenc, 2008. "Mathematical modeling of tumor growth in mice following low-level direct electric current," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 78(1), pages 112-120.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Soba, Alejandro & Suárez, Cecilia & González, Maraelys Morales & Cabrales, Luis Enrique Bergues & Pupo, Ana Elisa Bergues & Reyes, Juan Bory & Martínez Tassé, José Pablo, 2018. "Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 146(C), pages 160-176.
    2. Ciria, Héctor Manuel Camué & Cabrales, Luis Enrique Bergues & Aguilera, Andrés Ramírez & Nava, Juan José Godina & Joa, Javier Antonio González & García, Raudel Peña & González, Gustavo Sierra & Gonzál, 2012. "Influence of electrode array parameters used in electrotherapy on tumor growth kinetics: A mathematical simulation," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 82(8), pages 1396-1406.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Aguilera, Andrés Ramírez & Cabrales, Luis Enrique Bergues & Ciria, Héctor Manuel Camué & Pérez, Yudelmis Soler & González, Fidel Gilart & González, Maraelys Morales & Zamora, Lisset Ortíz & Palencia, , 2010. "Electric current density distribution in planar solid tumor and its surrounding healthy tissue generated by an electrode elliptic array used in electrotherapy," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 80(9), pages 1886-1902.
    2. Pupo, Ana Elisa Bergues & González, Maraelys Morales & Cabrales, Luis Enrique Bergues & Reyes, Juan Bory & Oria, Eduardo José Roca & Nava, Juan José Godina & Jiménez, Rolando Placeres & Sánchez, Franc, 2017. "3d current density in tumors and surrounding healthy tissues generated by a system of straight electrode arrays," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 138(C), pages 49-64.
    3. Cabrales, Luis Enrique Bergues & Montijano, Juan I. & Schonbek, Maria & Castañeda, Antonio Rafael Selva, 2018. "A viscous modified Gompertz model for the analysis of the kinetics of tumors under electrochemical therapy," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 151(C), pages 96-110.
    4. Ciria, Héctor Manuel Camué & Cabrales, Luis Enrique Bergues & Aguilera, Andrés Ramírez & Nava, Juan José Godina & Joa, Javier Antonio González & García, Raudel Peña & González, Gustavo Sierra & Gonzál, 2012. "Influence of electrode array parameters used in electrotherapy on tumor growth kinetics: A mathematical simulation," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 82(8), pages 1396-1406.
    5. Castañeda, Antonio Rafael Selva & Pozo, Josue Mariño del & Ramirez-Torres, Erick Eduardo & Oria, Eduardo José Roca & Vaillant, Sorangel Bolaños & Montijano, Juan I. & Cabrales, Luis Enrique Bergues, 2023. "Spatio temporal dynamics of direct current in treated anisotropic tumors," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 203(C), pages 609-632.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:matcom:v:79:y:2009:i:7:p:2091-2105. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/mathematics-and-computers-in-simulation/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.