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Growth curve mixture models with unknown covariance structures

Author

Listed:
  • Pan, Yating
  • Fei, Yu
  • Ni, Mingming
  • Nummi, Tapio
  • Pan, Jianxin

Abstract

Though playing an important role in longitudinal data analysis, the uses of growth curve models are constrained by the crucial assumption that the grouping design matrix is known. In this paper we propose a Gaussian mixture model within the framework of growth curve models which handles the problem caused by the unknown grouping matrix. This allows for a greater degree of flexibility in specifying the model and freeing the response matrix from following a single multivariate normal distribution. The new model is considered under two parsimonious covariance structures together with the unstructured covariance. The maximum likelihood estimation of the proposed model is studied using the ECM algorithm, which clusters growth curve data simultaneously. Data-driving methods are proposed to find various model parameters so as to create an appropriate model for complex growth curve data. Simulation studies are conducted to assess the performance of the proposed methods and real data analysis on gene expression clustering is made, showing that the proposed procedure works well in both, model fitting and growth curve data clustering.

Suggested Citation

  • Pan, Yating & Fei, Yu & Ni, Mingming & Nummi, Tapio & Pan, Jianxin, 2022. "Growth curve mixture models with unknown covariance structures," Journal of Multivariate Analysis, Elsevier, vol. 188(C).
    • Handle: RePEc:eee:jmvana:v:188:y:2022:i:c:s0047259x21001779
    DOI: 10.1016/j.jmva.2021.104904
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    References listed on IDEAS

    as
    1. Filipiak, Katarzyna & Klein, Daniel, 2017. "Estimation of parameters under a generalized growth curve model," Journal of Multivariate Analysis, Elsevier, vol. 158(C), pages 73-86.
    2. Sayantee Jana & Narayanaswamy Balakrishnan & Jemila S. Hamid, 2019. "Bayesian growth curve model useful for high-dimensional longitudinal data," Journal of Applied Statistics, Taylor & Francis Journals, vol. 46(5), pages 814-834, April.
    3. Jana, Sayantee & Balakrishnan, Narayanaswamy & Hamid, Jemila S., 2018. "Estimation of the parameters of the extended growth curve model under multivariate skew normal distribution," Journal of Multivariate Analysis, Elsevier, vol. 166(C), pages 111-128.
    4. Hu, Jianhua & Xin, Xin & You, Jinhong, 2014. "Model determination and estimation for the growth curve model via group SCAD penalty," Journal of Multivariate Analysis, Elsevier, vol. 124(C), pages 199-213.
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