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Vaccination against hepatitis B among prisoners in Iran: Accelerated vs. classic vaccination

Author

Listed:
  • Asli, Ali Asghar Zolghadr
  • Moghadami, Mohsen
  • Zamiri, Nima
  • Tolide-ei, Hamid Reza
  • Heydari, Seyyed Taghi
  • Alavian, Seyed Moayed
  • Lankarani, Kamran B.

Abstract

Background Prisoners and injecting drug users are at constant risk of hepatitis B virus (HBV) infection and the classic 6-months HBV vaccination might not provide immunization rapidly enough. In this randomized clinical trial we investigated the efficacy of an accelerated vaccination protocol vs. classic schedule among prisoners in Iran.Methods 180 prisoners were randomized into 2 vaccination groups; group A underwent accelerated vaccination at 0, 1, 4 and 8 weeks and group C were vaccinated at 0, 1 and 6 months. Antibody against Hepatitis-B surface-antigen (anti-HBs) was assessed at baseline, one, two, six and eight months after the first vaccine dose using immunoenzymatic assays. Seroprotection was defined as anti-HBs titer of 10Â IU/L or more. Anti-HBc and HBsAg were measured at baseline and 8th month to evaluate new HBV infection and failure of vaccination.Results Overall compliance was 100% and 90.4% in groups A and C respectively. While seroprotection rate at one month was significantly higher in group A (22.4%) compared to group C (4.7%), in the 8th month 78.8% and 93.4% seroprotection was achieved in groups A and C respectively (PÂ

Suggested Citation

  • Asli, Ali Asghar Zolghadr & Moghadami, Mohsen & Zamiri, Nima & Tolide-ei, Hamid Reza & Heydari, Seyyed Taghi & Alavian, Seyed Moayed & Lankarani, Kamran B., 2011. "Vaccination against hepatitis B among prisoners in Iran: Accelerated vs. classic vaccination," Health Policy, Elsevier, vol. 100(2-3), pages 297-304, May.
    • Handle: RePEc:eee:hepoli:v:100:y:2011:i:2-3:p:297-304
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    Cited by:

    1. Hui Jin & Zhaoying Tan & Xuefeng Zhang & Bei Wang & Yueyuan Zhao & Pei Liu, 2015. "Comparison of Accelerated and Standard Hepatitis B Vaccination Schedules in High-Risk Healthy Adults: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-16, July.

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