IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v202y2026ip1s0960077925014924.html

Studying synchronization of neural oscillators through NMDA-AMPA receptor interactions

Author

Listed:
  • Mofidi, Hamid
  • Wang, Yangyang

Abstract

This study investigates how NMDA and AMPA receptors influence synchronization in neural oscillators modeled by coupled Morris–Lecar systems. By analyzing the interplay between receptor kinetics, synaptic coupling strengths, and voltage-dependent magnesium block, we identify the mechanisms that govern neural synchronization. We show that fast AMPAR kinetics yield perfect synchrony at substantially lower coupling than NMDARs, which produce only near-synchrony even when Mg2+ block is absent. To resolve subtle regimes, we pair a time-domain mean phase difference (MPD) with the phase-locking value (PLV) and overlay bifurcation continuations (LP/HB/PD), exposing boundaries that PLV alone can miss. Although NMDARs sustain prolonged conductance, their slow decay and Mg2+ dependence blur spike timing and limit precise locking. These results provide a quantitative, mechanism-based account of glutamatergic control of synchrony and suggest experimentally testable predictions relevant to coordination deficits in disorders such as schizophrenia.

Suggested Citation

  • Mofidi, Hamid & Wang, Yangyang, 2026. "Studying synchronization of neural oscillators through NMDA-AMPA receptor interactions," Chaos, Solitons & Fractals, Elsevier, vol. 202(P1).
    • Handle: RePEc:eee:chsofr:v:202:y:2026:i:p1:s0960077925014924
    DOI: 10.1016/j.chaos.2025.117479
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077925014924
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2025.117479?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to

    for a different version of it.

    References listed on IDEAS

    as
    1. Shuo Li & Sumana Raychaudhuri & Stephen Alexander Lee & Marisa M. Brockmann & Jing Wang & Grant Kusick & Christine Prater & Sarah Syed & Hanieh Falahati & Raul Ramos & Tomas M. Bartol & Eric Hosy & Sh, 2021. "Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Keith B Doelling & M Florencia Assaneo, 2021. "Neural oscillations are a start toward understanding brain activity rather than the end," PLOS Biology, Public Library of Science, vol. 19(5), pages 1-12, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kyung Ah Han & Taek-Han Yoon & Jinhu Kim & Jusung Lee & Ju Yeon Lee & Gyubin Jang & Ji Won Um & Jong Kyoung Kim & Jaewon Ko, 2024. "Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Michael C. Anderson & Poorna A. Dharmasri & Martina Damenti & Sarah R. Metzbower & Rozita Laghaei & Thomas A. Blanpied & Aaron D. Levy, 2025. "Trans-synaptic molecular context of NMDA receptor nanodomains," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    3. Philipe R. F. Mendonça & Erica Tagliatti & Helen Langley & Dimitrios Kotzadimitriou & Criseida G. Zamora-Chimal & Yulia Timofeeva & Kirill E. Volynski, 2022. "Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:202:y:2026:i:p1:s0960077925014924. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.