IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v136y2020ics0960077920302113.html
   My bibliography  Save this article

Comparative study for optimal control nonlinear variable-order fractional tumor model

Author

Listed:
  • Sweilam, N.H.
  • AL-Mekhlafi, S.M.
  • Alshomrani, A.S.
  • Baleanu, D.

Abstract

This article presents a variable order nonlinear mathematical model and its optimal control for a Tumor under immune suppression. The formulation generalizes the one proposed by Kim et. al. consisting of eleven integer order differential equations. The new approach adopts a variable-order fractional model with the derivatives defined in the Caputo sense. Two control variables, one for immunotherapy and one for Chemotherapy, are proposed to eliminate or reduce the Tumor cells. A simple numerical technique called the nonstandard generalized Euler method is developed to solve the proposed optimal control problem. Moreover, the stability analysis and the truncation error are studied. Numerical simulations and comparative studies are implemented. Our findings disclose that the proposed scheme used here has two main advantages: it is faster than the generalized Euler scheme and it can reduce the number of Tumor cells in a proper process better than the second scheme.

Suggested Citation

  • Sweilam, N.H. & AL-Mekhlafi, S.M. & Alshomrani, A.S. & Baleanu, D., 2020. "Comparative study for optimal control nonlinear variable-order fractional tumor model," Chaos, Solitons & Fractals, Elsevier, vol. 136(C).
  • Handle: RePEc:eee:chsofr:v:136:y:2020:i:c:s0960077920302113
    DOI: 10.1016/j.chaos.2020.109810
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077920302113
    Download Restriction: Full text for ScienceDirect subscribers only

    File URL: https://libkey.io/10.1016/j.chaos.2020.109810?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Fathalla A. Rihan & Dumitru Baleanu & S. Lakshmanan & R. Rakkiyappan, 2014. "On Fractional SIRC Model with Salmonella Bacterial Infection," Abstract and Applied Analysis, Hindawi, vol. 2014, pages 1-9, April.
    2. Ghanbari, Behzad & Gómez-Aguilar, J.F., 2018. "Modeling the dynamics of nutrient–phytoplankton–zooplankton system with variable-order fractional derivatives," Chaos, Solitons & Fractals, Elsevier, vol. 116(C), pages 114-120.
    3. Gao, Wei & Ghanbari, Behzad & Baskonus, Haci Mehmet, 2019. "New numerical simulations for some real world problems with Atangana–Baleanu fractional derivative," Chaos, Solitons & Fractals, Elsevier, vol. 128(C), pages 34-43.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ali, Hegagi Mohamed & Ameen, Ismail Gad, 2021. "Optimal control strategies of a fractional order model for Zika virus infection involving various transmissions," Chaos, Solitons & Fractals, Elsevier, vol. 146(C).
    2. Ghanbari, Behzad & Günerhan, Hatıra & Srivastava, H.M., 2020. "An application of the Atangana-Baleanu fractional derivative in mathematical biology: A three-species predator-prey model," Chaos, Solitons & Fractals, Elsevier, vol. 138(C).
    3. Attia, Nourhane & Akgül, Ali & Seba, Djamila & Nour, Abdelkader, 2020. "An efficient numerical technique for a biological population model of fractional order," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).
    4. Hussain, Takasar & Aslam, Adnan & Ozair, Muhammad & Tasneem, Fatima & Gómez-Aguilar, J.F., 2021. "Dynamical aspects of pine wilt disease and control measures," Chaos, Solitons & Fractals, Elsevier, vol. 145(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Baleanu, Dumitru & Jajarmi, Amin & Mohammadi, Hakimeh & Rezapour, Shahram, 2020. "A new study on the mathematical modelling of human liver with Caputo–Fabrizio fractional derivative," Chaos, Solitons & Fractals, Elsevier, vol. 134(C).
    2. Sekerci, Yadigar & Ozarslan, Ramazan, 2020. "Respiration Effect on Plankton–Oxygen Dynamics in view of non-singular time fractional derivatives," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 553(C).
    3. Zafar, Zain Ul Abadin & Ali, Nigar & Baleanu, Dumitru, 2021. "Dynamics and numerical investigations of a fractional-order model of toxoplasmosis in the population of human and cats," Chaos, Solitons & Fractals, Elsevier, vol. 151(C).
    4. Ghanbari, Behzad & Günerhan, Hatıra & Srivastava, H.M., 2020. "An application of the Atangana-Baleanu fractional derivative in mathematical biology: A three-species predator-prey model," Chaos, Solitons & Fractals, Elsevier, vol. 138(C).
    5. Zafar, Zain Ul Abadin & Zaib, Sumera & Hussain, Muhammad Tanveer & Tunç, Cemil & Javeed, Shumaila, 2022. "Analysis and numerical simulation of tuberculosis model using different fractional derivatives," Chaos, Solitons & Fractals, Elsevier, vol. 160(C).
    6. Ghanbari, Behzad & Djilali, Salih, 2020. "Mathematical analysis of a fractional-order predator-prey model with prey social behavior and infection developed in predator population," Chaos, Solitons & Fractals, Elsevier, vol. 138(C).
    7. Zafar, Zain Ul Abadin & Younas, Samina & Hussain, Muhammad Tanveer & Tunç, Cemil, 2021. "Fractional aspects of coupled mass-spring system," Chaos, Solitons & Fractals, Elsevier, vol. 144(C).
    8. Sekerci, Yadigar & Ozarslan, Ramazan, 2020. "Oxygen-plankton model under the effect of global warming with nonsingular fractional order," Chaos, Solitons & Fractals, Elsevier, vol. 132(C).
    9. Saad, Khaled M. & Srivastava, H.M. & Gómez-Aguilar, J.F., 2020. "A Fractional Quadratic autocatalysis associated with chemical clock reactions involving linear inhibition," Chaos, Solitons & Fractals, Elsevier, vol. 132(C).
    10. Allahviranloo, Tofigh & Ghanbari, Behzad, 2020. "On the fuzzy fractional differential equation with interval Atangana–Baleanu fractional derivative approach," Chaos, Solitons & Fractals, Elsevier, vol. 130(C).
    11. Asamoah, Joshua Kiddy K. & Okyere, Eric & Yankson, Ernest & Opoku, Alex Akwasi & Adom-Konadu, Agnes & Acheampong, Edward & Arthur, Yarhands Dissou, 2022. "Non-fractional and fractional mathematical analysis and simulations for Q fever," Chaos, Solitons & Fractals, Elsevier, vol. 156(C).
    12. Khader, M.M. & Inc, Mustafa, 2021. "Numerical technique based on the interpolation with Lagrange polynomials to analyze the fractional variable-order mathematical model of the hepatitis C with different types of virus genome," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    13. Boukhouima, Adnane & Hattaf, Khalid & Lotfi, El Mehdi & Mahrouf, Marouane & Torres, Delfim F.M. & Yousfi, Noura, 2020. "Lyapunov functions for fractional-order systems in biology: Methods and applications," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    14. Deniz, Sinan, 2021. "Optimal perturbation iteration method for solving fractional FitzHugh-Nagumo equation," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).
    15. Songkran Pleumpreedaporn & Chanidaporn Pleumpreedaporn & Jutarat Kongson & Chatthai Thaiprayoon & Jehad Alzabut & Weerawat Sudsutad, 2022. "Dynamical Analysis of Nutrient-Phytoplankton-Zooplankton Model with Viral Disease in Phytoplankton Species under Atangana-Baleanu-Caputo Derivative," Mathematics, MDPI, vol. 10(9), pages 1-33, May.
    16. Zeid, Samaneh Soradi, 2019. "Approximation methods for solving fractional equations," Chaos, Solitons & Fractals, Elsevier, vol. 125(C), pages 171-193.
    17. Zhang, Zhe & Ai, Zhaoyang & Zhang, Jing & Cheng, Fanyong & Liu, Feng & Ding, Can, 2020. "A general stability criterion for multidimensional fractional-order network systems based on whole oscillation principle for small fractional-order operators," Chaos, Solitons & Fractals, Elsevier, vol. 131(C).
    18. Yuanlin Ma & Xingwang Yu, 2022. "Stationary Probability Density Analysis for the Randomly Forced Phytoplankton–Zooplankton Model with Correlated Colored Noises," Mathematics, MDPI, vol. 10(14), pages 1-11, July.
    19. Chatterjee, Amar Nath & Ahmad, Bashir, 2021. "A fractional-order differential equation model of COVID-19 infection of epithelial cells," Chaos, Solitons & Fractals, Elsevier, vol. 147(C).
    20. Rihan, F.A. & Al-Mdallal, Q.M. & AlSakaji, H.J. & Hashish, A., 2019. "A fractional-order epidemic model with time-delay and nonlinear incidence rate," Chaos, Solitons & Fractals, Elsevier, vol. 126(C), pages 97-105.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:136:y:2020:i:c:s0960077920302113. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.