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Analyzing gas crossover risk of proton exchange membrane water electrolyzer through a perspective of disease prevention and treatment

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  • Liu, Zongqi
  • Ren, Jingjie
  • Sun, Weicheng
  • Yu, Di
  • Wang, Yuan
  • Bi, Mingshu

Abstract

Scale-up and commercial applications (renewable energy hydrogen production) of green hydrogen can reduce carbon emissions and contribute to energy sustainability. Safety of proton exchange membrane water electrolysis (PEMWE) is critical for the large-scale, long-term operation of renewable energy hydrogen production system. Herein, the gas crossover risk in PEM electrolyzers and its response strategies are reviewed. The root causes of gas crossover risk are investigated. Strategies named “nearby therapy”, “remote therapy”, and “special therapy”, as well as a safety concept of “rapid risk transfer, monitoring, and regulation” are proposed to view gas crossover based on the theories and therapies of Traditional Chinese Medicine and Modern Medicine. These ideas provide a comprehensive framework to multi-factor interrelated safety problems in industrial equipment. Furthermore, this review highlights the non-independence of safety decisions with cost, efficiency, energy consumption, durability, and stability. In the end, component design strategies and related technology trends are discussed, which are of great significance for the high-end, intelligent, and large-scale development of PEMWE.

Suggested Citation

  • Liu, Zongqi & Ren, Jingjie & Sun, Weicheng & Yu, Di & Wang, Yuan & Bi, Mingshu, 2026. "Analyzing gas crossover risk of proton exchange membrane water electrolyzer through a perspective of disease prevention and treatment," Applied Energy, Elsevier, vol. 403(PA).
    • Handle: RePEc:eee:appene:v:403:y:2026:i:pa:s0306261925017581
    DOI: 10.1016/j.apenergy.2025.127028
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    1. David Cyranoski, 2018. "Why Chinese medicine is heading for clinics around the world," Nature, Nature, vol. 561(7724), pages 448-450, September.
    2. Xin Liu & Yi Li & Jiandang Xue & Weikang Zhu & Junfeng Zhang & Yan Yin & Yanzhou Qin & Kui Jiao & Qing Du & Bowen Cheng & Xupin Zhuang & Jianxin Li & Michael D. Guiver, 2019. "Magnetic field alignment of stable proton-conducting channels in an electrolyte membrane," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    3. Kiane Kleijne & Mark A. J. Huijbregts & Florian Knobloch & Rosalie Zelm & Jelle P. Hilbers & Heleen Coninck & Steef V. Hanssen, 2024. "Worldwide greenhouse gas emissions of green hydrogen production and transport," Nature Energy, Nature, vol. 9(9), pages 1139-1152, September.
    4. Fu, J.L. & Qu, Z.G. & Zhang, J.F. & Zhang, G.B., 2023. "Performance analysis of PEMEC with non-uniform deformation based on a comprehensive numerical framework coupling image recognition and CFD," Applied Energy, Elsevier, vol. 350(C).
    5. Fernando Rocha & Christos Georgiadis & Kevin Droogenbroek & Renaud Delmelle & Xavier Pinon & Grzegorz Pyka & Greet Kerckhofs & Franz Egert & Fatemeh Razmjooei & Syed-Asif Ansar & Shigenori Mitsushima , 2024. "Proton exchange membrane-like alkaline water electrolysis using flow-engineered three-dimensional electrodes," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Chunchun Ye & Anqi Wang & Charlotte Breakwell & Rui Tan & C. Grazia Bezzu & Elwin Hunter-Sellars & Daryl R. Williams & Nigel P. Brandon & Peter A. A. Klusener & Anthony R. Kucernak & Kim E. Jelfs & Ne, 2022. "Development of efficient aqueous organic redox flow batteries using ion-sieving sulfonated polymer membranes," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    7. Kiane Kleijne & Mark A. J. Huijbregts & Florian Knobloch & Rosalie Zelm & Jelle P. Hilbers & Heleen Coninck & Steef V. Hanssen, 2024. "Author Correction: Worldwide greenhouse gas emissions of green hydrogen production and transport," Nature Energy, Nature, vol. 9(11), pages 1449-1449, November.
    8. Zheng-Jie Chen & Jiuyi Dong & Jiajing Wu & Qiting Shao & Na Luo & Minwei Xu & Yuanmiao Sun & Yongbing Tang & Jing Peng & Hui-Ming Cheng, 2023. "Acidic enol electrooxidation-coupled hydrogen production with ampere-level current density," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    9. Haiyang Zhan & Zichao Yuan & Yu Li & Liang Zhang & Hui Liang & Yuhui Zhao & Zhiguo Wang & Lei Zhao & Shile Feng & Yahua Liu, 2023. "Versatile bubble maneuvering on photopyroelectric slippery surfaces," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    10. Sossina M. Haile & Dane A. Boysen & Calum R. I. Chisholm & Ryan B. Merle, 2001. "Solid acids as fuel cell electrolytes," Nature, Nature, vol. 410(6831), pages 910-913, April.
    11. Shenbin Liu & Zhifu Wang & Yangshuai Su & Lu Qi & Wei Yang & Mingzhou Fu & Xianghong Jing & Yanqing Wang & Qiufu Ma, 2021. "A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis," Nature, Nature, vol. 598(7882), pages 641-645, October.
    12. Wendong Wang & Jaakko V. I. Timonen & Andreas Carlson & Dirk-Michael Drotlef & Cathy T. Zhang & Stefan Kolle & Alison Grinthal & Tak-Sing Wong & Benjamin Hatton & Sung Hoon Kang & Stephen Kennedy & Jo, 2018. "Multifunctional ferrofluid-infused surfaces with reconfigurable multiscale topography," Nature, Nature, vol. 559(7712), pages 77-82, July.
    13. Davide Tonelli & Lorenzo Rosa & Paolo Gabrielli & Ken Caldeira & Alessandro Parente & Francesco Contino, 2023. "Global land and water limits to electrolytic hydrogen production using wind and solar resources," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    14. Mohammad Alobeid & Selahattin Çelik & Hasan Ozcan & Bahman Amini Horri, 2024. "Multi-Dimensional Modelling of Bioinspired Flow Channels Based on Plant Leaves for PEM Electrolyser," Energies, MDPI, vol. 17(17), pages 1-20, September.
    15. Sayed-Ahmed, H. & Toldy, Á.I. & Santasalo-Aarnio, A., 2024. "Dynamic operation of proton exchange membrane electrolyzers—Critical review," Renewable and Sustainable Energy Reviews, Elsevier, vol. 189(PA).
    16. Li, Yuxuan & Li, Hongkun & Liu, Weiqun & Zhu, Qiao, 2024. "Optimization of membrane thickness for proton exchange membrane electrolyzer considering hydrogen production efficiency and hydrogen permeation phenomenon," Applied Energy, Elsevier, vol. 355(C).
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