IDEAS home Printed from
MyIDEAS: Log in (now much improved!) to save this article

A parametric dynamic survival model applied to breast cancer survival times

Listed author(s):
  • K. Hemming
  • J. E. H. Shaw
Registered author(s):

    Much current analysis of cancer registry data uses the semiparametric proportional hazards Cox model. In this paper, the time-dependent effect of various prognostic indicators on breast cancer survival times from the West Midlands Cancer Intelligence Unit are investigated. Using Bayesian methodology and Markov chain Monte Carlo estimation methods, we develop a parametric dynamic survival model which avoids the proportional hazards assumption. The model has close links to that developed by both Gamerman and Sinha and co-workers: the log-base-line hazard and covariate effects are piecewise constant functions, related between intervals by a simple stochastic evolution process. Here this evolution is assigned a parametric distribution, with a variance that is further included as a hyperparameter. To avoid problems of convergence within the Gibbs sampler, we consider using a reparameterization. It is found that, for some of the prognostic indicators considered, the estimated effects change with increasing follow-up time. In general those prognostic indicators which are thought to be representative of the most hazardous groups (late-staged tumour and oldest age group) have a declining effect. Copyright 2002 Royal Statistical Society.

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.

    File URL:
    File Function: link to full text
    Download Restriction: Access to full text is restricted to subscribers.

    As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.

    Article provided by Royal Statistical Society in its journal Journal of the Royal Statistical Society: Series C (Applied Statistics).

    Volume (Year): 51 (2002)
    Issue (Month): 4 ()
    Pages: 421-435

    in new window

    Handle: RePEc:bla:jorssc:v:51:y:2002:i:4:p:421-435
    Contact details of provider: Postal:
    12 Errol Street, London EC1Y 8LX, United Kingdom

    Phone: -44-171-638-8998
    Fax: -44-171-256-7598
    Web page:

    More information through EDIRC

    Order Information: Web:

    No references listed on IDEAS
    You can help add them by filling out this form.

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    When requesting a correction, please mention this item's handle: RePEc:bla:jorssc:v:51:y:2002:i:4:p:421-435. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Wiley-Blackwell Digital Licensing)

    or (Christopher F. Baum)

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    This information is provided to you by IDEAS at the Research Division of the Federal Reserve Bank of St. Louis using RePEc data.