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A useful design utilizing the information fraction in a group sequential clinical trial with censored survival data

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  • Chih‐Yuan Hsu
  • Chen‐Hsin Chen
  • Ken‐Ning Hsu
  • Ya‐Hung Lu

Abstract

Lan and DeMets (1983) proposed the alpha spending function for group sequential trials to permit the use of unspecified frequencies and timings of interim analyses in the trial design. Regarding a trial with censored time to endpoint, Lan and DeMets (1989) later defined information time at an interim analysis in a maximum duration trial. To compare two survival curves utilizing such a design, information times for group sequential logrank and Wilcoxon‐type statistics have been developed by assuming that the survival time follows an exponential distribution or a Weibull distribution without considering the censoring distribution. To better address the practical concerns inherent in clinical trials with survival endpoints, we present a new approach to adequately design a group sequential trial using the Harrington–Fleming (1982) test based on our proposed information fractions by assuming the censoring distribution depends on the patient's accrual time according to various entry distributions and by extending the underlying survival distribution to the generalized gamma distribution. We also determine associated sample sizes, expected number of events and expected stopping time. Two phase III trials of non‐small‐cell lung cancer originally designed using fixed‐sample tests are utilized to illustrate the potential advantages of using a group sequential design with the proposed approach. This enhanced method facilitates the design and analysis of group sequential clinical trials studying survival endpoints by increasing implemental flexibility.

Suggested Citation

  • Chih‐Yuan Hsu & Chen‐Hsin Chen & Ken‐Ning Hsu & Ya‐Hung Lu, 2019. "A useful design utilizing the information fraction in a group sequential clinical trial with censored survival data," Biometrics, The International Biometric Society, vol. 75(1), pages 133-143, March.
    • Handle: RePEc:bla:biomet:v:75:y:2019:i:1:p:133-143
    DOI: 10.1111/biom.12925
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    References listed on IDEAS

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    1. Constantine E. Frangakis & Donald B. Rubin, 2001. "Addressing an Idiosyncrasy in Estimating Survival Curves Using Double Sampling in the Presence of Self-Selected Right Censoring," Biometrics, The International Biometric Society, vol. 57(2), pages 333-342, June.
    2. Constantine E. Frangakis & Donald B. Rubin, 2001. "Rejoinder to Discussions on Addressing an Idiosyncrasy in Estimating Survival Curves Using Double Sampling in the Presence of Self-Selected Right Censoring," Biometrics, The International Biometric Society, vol. 57(2), pages 351-353, June.
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