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Neuroprotective Effects of Tetracarpidium Conophorum in Wistar Rats Treated With Cadmium Acetate

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Listed:
  • Chinenye Mary Okorochi

    (Babcock University Department of Medical Laboratory Science Ogun State)

  • Precious Chinonso Nwafor-Richard

    (Babcock University Department of Medical Laboratory Science Ogun State)

  • Enoch Chibuike Okorochi

    (Joseph Ayo Babalola University Osun State)

  • Olushola Olakunle Jegede

    (Federal Medical Centre Department of Anatomical Pathology Umuahia Abia State)

  • Edoiseh Ehidiamhen Felix

    (David Umahi, Federal University of Health Sciences, Department of Anatomic Pathology, Faculty of Basic Clinical Sciences, Uburu, Ebonyi State)

  • Stanley Emeka Ogbata

    (Federal Medical Centre Department of Anatomical Pathology Umuahia Abia State)

Abstract

Cadmium (Cd) is an environmental heavy metal associated with neurotoxicity. This study investigates the neuroprotective effects of oilseed from Tetracarpidium conophorum (Müll. Arg.) on the medulla oblongata of Wistar rats (Rattus norvegicus) exposed to cadmium acetate (Cd(CH₃COO)₂) and behavioral changes in the medulla oblongata of Wistar rats. . Thirty adult female Wistar rats were allocated into five groups (n = 6): control (normal saline), sham (pellets/water only), cadmium acetate only (3.5 mg/kg, i.p.), cadmium acetate + T. conophorum oil seed (3.5 mg/kg i.p. + 0.5 ml/kg orally), and oil seed only (0.5 ml/kg orally). Treatments lasted 30 days. Body weight and neurobehavior (beam walk test) were recorded. Brain tissues were examined histologically (H&E, Luxol Fast Blue). Data were analyzed by one-way ANOVA followed by Tukey’s post-hoc test; values are mean ± SEM; p

Suggested Citation

  • Chinenye Mary Okorochi & Precious Chinonso Nwafor-Richard & Enoch Chibuike Okorochi & Olushola Olakunle Jegede & Edoiseh Ehidiamhen Felix & Stanley Emeka Ogbata, 2025. "Neuroprotective Effects of Tetracarpidium Conophorum in Wistar Rats Treated With Cadmium Acetate," International Journal of Research and Innovation in Social Science, International Journal of Research and Innovation in Social Science (IJRISS), vol. 12(10), pages 322-335, October.
    • Handle: RePEc:bcp:journl:v:12:y:2025:i:10:p:322-335
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