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Age-related changes in total and high-density-lipoprotein cholesterol in elderly Dutch men

Author

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  • Weijenberg, M.P.
  • Feskens, E.J.M.
  • Kromhout, D.

Abstract

Objectives. This study investigated changes in total and high-density- lipoprotein cholesterol (HDL) concentrations with age and time in elderly men. Methods. A cohort of men born between 1900 and 1920 from the Dutch town of Zutphen was examined in 1977 and 1978 (n = 571), 1985 (n = 885), 1990 (n = 555), and 1993 (n = 345). Linear regression analysis and random-effects models were used to assess cross-sectional and longitudinal age- and time- related changes in cholesterol concentrations. Results. In both cross- sectional and longitudinal analyses, total cholesterol decreased by 0.04 mmol/L a year with age. The longitudinal change was observed in the entire population as well as in men who participated in all four examinations (n = 135) and in a subgroup of men who were free of common chronic diseases, were not on cholesterol-lowering medication or a prescribed diet, and rated themselves as being 'healthy' (n = 64). HDL cholesterol did not change significantly with age neither on a cross-sectional nor on a longitudinal basis. Conclusions. Among elderly men, total cholesterol diminishes with age both on a cross-sectional and on a longitudinal basis; HDL cholesterol does not vary with age in anyway.

Suggested Citation

  • Weijenberg, M.P. & Feskens, E.J.M. & Kromhout, D., 1996. "Age-related changes in total and high-density-lipoprotein cholesterol in elderly Dutch men," American Journal of Public Health, American Public Health Association, vol. 86(6), pages 798-803.
    • Handle: RePEc:aph:ajpbhl:1996:86:6:798-803_1
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    Cited by:

    1. Brian Downer & Steven Estus & Yuriko Katsumata & David W. Fardo, 2014. "Longitudinal Trajectories of Cholesterol from Midlife through Late Life according to Apolipoprotein E Allele Status," IJERPH, MDPI, vol. 11(10), pages 1-31, October.

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