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Drinking water mutagenicity and gastrointestinal and urinary tract cancers: An ecological study in Finland

Author

Listed:
  • Koivusalo, M.
  • Jaakkola, J.J.K.
  • Vartiainen, T.
  • Hakulinen, T.
  • Karjalainen, S.
  • Pukkala, E.
  • Tuomisto, J.

Abstract

Objectives. The purpose of this study was to investigate the relationship between exposure to mutagenic drinking water and cancers of the gastrointestinal and urinary track. Methods. Past exposure to drinking water mutagenicity was assessed in 56 Finnish municipalities for the years 1955 and 1970. The cases of bladder, kidney, stomach, colon, and rectum cancers were derived from two periods (1967 to 1976 and 1977 to 1986). Age, sex, social class, urban living, and time period were taken into account in the Poisson regression analysis. Results. Statistically significant exposure-response association was observed between exposure and incidence of bladder, kidney, and stomach cancers. In an ordinary municipality using chlorinated surface water, this exposure would indicate a relative risk of 1.2 for bladder cancer and of 1.2 to 1.4 for kidney cancer compared with municipalities where nonmutagenic drinking water was consumed. Conclusions. The acidic mutagenic compounds present in drinking water may play a role in the etiology of kidney and bladder cancers, but, because the results are based on aggregate data, they should be interpreted with caution.

Suggested Citation

  • Koivusalo, M. & Jaakkola, J.J.K. & Vartiainen, T. & Hakulinen, T. & Karjalainen, S. & Pukkala, E. & Tuomisto, J., 1994. "Drinking water mutagenicity and gastrointestinal and urinary tract cancers: An ecological study in Finland," American Journal of Public Health, American Public Health Association, vol. 84(8), pages 1223-1228.
    • Handle: RePEc:aph:ajpbhl:1994:84:8:1223-1228_8
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    Cited by:

    1. S. Michelle Driedger & John Eyles & Susan D. Elliott & Donald C. Cole, 2002. "Constructing Scientific Authorities: Issue Framing of Chlorinated Disinfection Byproducts in Public Health," Risk Analysis, John Wiley & Sons, vol. 22(4), pages 789-802, August.
    2. Peng Zhou & Long Tian & Nigel Graham & Shian Song & Renzun Zhao & Muhammad Saboor Siddique & Ying Hu & Xianyong Cao & Yonglong Lu & Menachem Elimelech & Wenzheng Yu, 2024. "Spatial patterns and environmental functions of dissolved organic matter in grassland soils of China," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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