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Benzodiazepine tranquilizers and the risk of accidental injury

Author

Listed:
  • Oster, G.
  • Huse, D.M.
  • Adams, S.F.
  • Imbimbo, J.
  • Russell, M.W.

Abstract

To determine whether benzodiazepine tranquilizers increase the risk of accidental injury requiring medical attention, we used pharmacy claims submitted to a large third-party payer to identify 4,554 persons who had been prescribed these agents and a matched control group of 13,662 persons who had been prescribed drugs other than benzodiazepines. We then used diagnoses recorded on claims submitted by medical care providers to identify all accident-related care received by these persons during three months before their first-observed prescription for a benzodiazepine or nonbenzodiazepine agent, respectively, and six months subsequently. We found accident-related care was more likely among persons who had been prescribed benzodiazepines; among these persons, the probability of an accident-related medical encounter was higher during months in which a prescription for a benzodiazepine had recently been filled compared to other months; and persons who had filled three or more prescriptions for these agents in the six months following initiation of therapy had a significantly higher risk of an accident-related medical event than those who had filled only one such prescription. Approximately two-fold risks of accident-related care were found, after controlling for age, sex, and prior utilization.

Suggested Citation

  • Oster, G. & Huse, D.M. & Adams, S.F. & Imbimbo, J. & Russell, M.W., 1990. "Benzodiazepine tranquilizers and the risk of accidental injury," American Journal of Public Health, American Public Health Association, vol. 80(12), pages 1467-1470.
    • Handle: RePEc:aph:ajpbhl:1990:80:12:1467-1470_9
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