School-based measles outbreaks: Correlation of age at immunization with risk of disease

During the Spring of 1978, students with a history of previous measles vaccination accounted for over three-fourths of 203 cases of measles in a metropolitan county. Seventy cases occurred in two schools where 99% of the students were vaccinated. We analyzed countywide data to determine past patterns of measles vaccination, including outbreak control and vaccination update clinics. We also examined records of children from the 2 schools to assess the relationship between disease incidence and age at vaccination. When susceptibility was determined by trained health workers rather than by parents, fewer doses of measles vaccine were estimated to be needed. The majority of cases occurred among children 5 to 9 years old. Attack rates were higher for children vaccinated at 12 mth of age or younger than for those vaccinated at 13 mth of age or older. There were no significant differences in attack rates among children vaccinated at 13 mth of age or older. These findings support recommendations for delaying routine measles vaccination until after 12 mth of age and suggest that, during outbreaks, all children vaccinated prior to 13 mth of age be revaccinated.