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Prevalence of hepatitis B in 27 Michigan hemodialysis centers

Author

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  • Mayor, G.H.
  • Hourani, M.R.
  • Greenbaum, D.S.
  • Jevitz Patterson, M.

Abstract

A large epidemiological survey of in-hospital chronic hemodialysis patients was conducted in 27 (93 per cent) of the 29 dialysis centers in Michigan. Serum was collected from 699 patients on chronic maintenance hemodialysis for periods from one month to eight years. Hepatitis B surface antigen (HB(s)Ag) was determined in all patients by radioimmunoassay and positive samples were confirmed by specific neutralization. Antibody against HB(s)Ag (anti-HB(s)) was determined by radioimmunoassay in 110 HB(s)Ag negative patients from six dialysis units with a high prevalence of hepatitis B. HB(s)Ag was detected in 80 (11.4%) patients distributed among 21 (78%) of 27 dialysis units and anti-HB(s) in 34 (31%) patients from the selected dialysis units. The prevalence of HB(s)Ag was related to duration of dialysis, number of blood transfusions, and to a history of bilateral nephrectomy, but not to age, sex, race, nor the underlying renal disease. 21 (26%) of the 80 HB(s)Ag positive patients had not been previously identified by the clinical laboratories of their institutions. Since preventive measures were not taken in the care of these inapparent carriers of HB(s)Ag, they represent an unrecognized risk.

Suggested Citation

  • Mayor, G.H. & Hourani, M.R. & Greenbaum, D.S. & Jevitz Patterson, M., 1979. "Prevalence of hepatitis B in 27 Michigan hemodialysis centers," American Journal of Public Health, American Public Health Association, vol. 69(6), pages 581-584.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.69.6.581_3
    DOI: 10.2105/AJPH.69.6.581
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