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Promoting transparency in pharmaceutical industry-sponsored research

Author

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  • Ross, J.S.
  • Gross, C.P.
  • Krumholz, H.M.

Abstract

Strong, evidence-based practice requires that objective, unbiased research be available to inform individual clinical decisions, systematic reviews, meta-analyses, and expert guideline recommendations. Industry has used seeding trials, publication planning, messaging,ghostwriting,and selective publication and reporting of trial outcomes to distort the medical literature and undermine clinical trial research by obscuring information relevant to patients and physicians. Policies that promote transparency in the clinical trial research process, through improved and expanded disclosure of investigator contributions and funding, comprehensive publicly available trial registration, and independent analysis of clinical trial data analysis may address these subversive practices by improving accountability among industry and investigators. Minimizing marketing's impact on clinical trial research and strengthening the science will protect medical literature's integrity and the public's health.

Suggested Citation

  • Ross, J.S. & Gross, C.P. & Krumholz, H.M., 2012. "Promoting transparency in pharmaceutical industry-sponsored research," American Journal of Public Health, American Public Health Association, vol. 102(1), pages 72-80.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2011.300187_7
    DOI: 10.2105/AJPH.2011.300187
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    Cited by:

    1. John C. Besley & Nagwan R. Zahry & Aaron McCright & Kevin C. Elliott & Norbert E. Kaminski & Joseph D. Martin, 2019. "Conflict of Interest Mitigation Procedures May Have Little Influence on the Perceived Procedural Fairness of Risk‐Related Research," Risk Analysis, John Wiley & Sons, vol. 39(3), pages 571-585, March.
    2. Ferrán Catalá-López & Gabriel Sanfélix-Gimeno & Manuel Ridao & Salvador Peiró, 2013. "When Are Statins Cost-Effective in Cardiovascular Prevention? A Systematic Review of Sponsorship Bias and Conclusions in Economic Evaluations of Statins," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-1, July.

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