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Searching For Causes Of Necrotising Enterocolitis. An Application Of Propensity Matching

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  • Longford Nicholas T.

    (Imperial College London, ; London, ; United Kingdom)

Abstract

Necrotising enterocolitis (NEC) is a disease of the gastrointestinal tract afflicting preterm-born infants in the first few weeks of their lives. We estimate the effect of changing the feeding regimen of infants in their first 14 postnatal days by analysing the data from the UK National Neonatal Research Database. We avoid some problems with drawing causal inferences from observational data by reducing the analysis to the infants who spent the first 14 postnatal days (or longer) in neonatal care and for whom NEC was not suspected in this period. This reduction enables us to use summaries of the feeding regimen in this period as background variables in a potential outcomes framework. Large size of the cohort is a distinct advantage of our study. Its results inform the design of a randomised clinical trial for preventing NEC, and the choice of its active treatment(s) in particular.

Suggested Citation

  • Longford Nicholas T., 2018. "Searching For Causes Of Necrotising Enterocolitis. An Application Of Propensity Matching," Statistics in Transition New Series, Polish Statistical Association, vol. 19(1), pages 87-117, March.
    • Handle: RePEc:vrs:stintr:v:19:y:2018:i:1:p:87-117:n:2
    DOI: 10.21307/stattrans-2018-006
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    References listed on IDEAS

    as
    1. Donald B. Rubin, 2005. "Causal Inference Using Potential Outcomes: Design, Modeling, Decisions," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 322-331, March.
    2. Imbens,Guido W. & Rubin,Donald B., 2015. "Causal Inference for Statistics, Social, and Biomedical Sciences," Cambridge Books, Cambridge University Press, number 9780521885881.
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