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R&D dynamics and scientific breakthroughs in HIV/AIDS drugs development: the case of Integrase Inhibitors

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  • J. J. Winnink

    (Leiden University
    Leiden University Dual PhD Centre The Hague
    Netherlands Patent Office (a Division of Netherlands Enterprise Agency))

  • Robert J. W. Tijssen

    (Leiden University
    Stellenbosch University)

Abstract

Transformations and applications of scientific knowledge into new technologies are usually complex interactive processes. Is it possible to detect, from bibliographic information alone, structural alterations and significant events within these processes that may indicate breakthrough discoveries? In this empirical study we focus on R&D processes leading to HIV/AIDS medicines called Integrase Inhibitors. Where scientific progress and discoveries are reflected in research papers, patents signify inventions and technological achievements. Our temporal analysis of distinctive events in this R&D area, tracing trends within both bibliographic information sources, is driven by three bibliometric indicators: (1) contributions of ‘bridging researchers’ who are also inventors, (2) ‘key papers’ that subject experts in the field considered milestones in the research process, and (3) the multidisciplinary impact of those papers. The main results indicate that a combination of key papers, bridging researchers and multidisciplinary impact might help track potential ‘Charge type’ breakthrough developments.

Suggested Citation

  • J. J. Winnink & Robert J. W. Tijssen, 2014. "R&D dynamics and scientific breakthroughs in HIV/AIDS drugs development: the case of Integrase Inhibitors," Scientometrics, Springer;Akadémiai Kiadó, vol. 101(1), pages 1-16, October.
    • Handle: RePEc:spr:scient:v:101:y:2014:i:1:d:10.1007_s11192-014-1330-7
    DOI: 10.1007/s11192-014-1330-7
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    1. Manuel Trajtenberg, 1990. "A Penny for Your Quotes: Patent Citations and the Value of Innovations," RAND Journal of Economics, The RAND Corporation, vol. 21(1), pages 172-187, Spring.
    2. Martin Meyer, 2006. "Are Co-Active Researchers on Top of their Class? An Exploratory Comparison of Inventor-Authors with their Non-Inventing Peers in Nano-Science and Technology," SPRU Working Paper Series 144, SPRU - Science Policy Research Unit, University of Sussex Business School.
    3. Meyer, Martin, 2006. "Are patenting scientists the better scholars?: An exploratory comparison of inventor-authors with their non-inventing peers in nano-science and technology," Research Policy, Elsevier, vol. 35(10), pages 1646-1662, December.
    4. Chen, Chaomei & Chen, Yue & Horowitz, Mark & Hou, Haiyan & Liu, Zeyuan & Pellegrino, Donald, 2009. "Towards an explanatory and computational theory of scientific discovery," Journal of Informetrics, Elsevier, vol. 3(3), pages 191-209.
    5. Lissoni, Francesco, 2010. "Academic inventors as brokers," Research Policy, Elsevier, vol. 39(7), pages 843-857, September.
    6. Cockburn, Iain M & Henderson, Rebecca M, 1998. "Absorptive Capacity, Coauthoring Behavior, and the Organization of Research in Drug Discovery," Journal of Industrial Economics, Wiley Blackwell, vol. 46(2), pages 157-182, June.
    7. Chaomei Chen, 2012. "Predictive effects of structural variation on citation counts," Journal of the American Society for Information Science and Technology, Association for Information Science & Technology, vol. 63(3), pages 431-449, March.
    8. Gautam Ahuja & Curba Morris Lampert, 2001. "Entrepreneurship in the large corporation: a longitudinal study of how established firms create breakthrough inventions," Strategic Management Journal, Wiley Blackwell, vol. 22(6‐7), pages 521-543, June.
    9. Noyons, E. C. M. & van Raan, A. F. J. & Grupp, H. & Schmoch, U., 1994. "Exploring the science and technology interface: inventor-author relations in laser medicine research," Research Policy, Elsevier, vol. 23(4), pages 443-457, July.
    10. Tijssen, Robert J. W., 2002. "Science dependence of technologies: evidence from inventions and their inventors," Research Policy, Elsevier, vol. 31(4), pages 509-526, May.
    11. Iain M. Cockburn & Rebecca M. Henderson, 1998. "Absorptive Capacity, Coauthoring Behavior, and the Organization of Research in Drug Discovery," Journal of Industrial Economics, Wiley Blackwell, vol. 46(2), pages 157-182, June.
    12. Luís M. A. Bettencourt & David I. Kaiser & Jasleen Kaur & Carlos Castillo-Chávez & David E. Wojick, 2008. "Population modeling of the emergence and development of scientific fields," Scientometrics, Springer;Akadémiai Kiadó, vol. 75(3), pages 495-518, June.
    13. Diana Hicks, 2000. "360 degree linkage analysis," Research Evaluation, Oxford University Press, vol. 9(2), pages 133-143, August.
    14. Ryuzo Furukawa & Akira Goto, 2006. "Core scientists and innovation in Japanese electronics companies," Scientometrics, Springer;Akadémiai Kiadó, vol. 68(2), pages 227-240, August.
    15. Marc Julius & Charles E. Berkoff & Alvin E. Strack & Frank Krasovec & A. Douglas Bender, 1977. "A very early warning system for the rapid identification and transfer of new technology," Journal of the American Society for Information Science, Association for Information Science & Technology, vol. 28(3), pages 170-174, May.
    16. Chaomei Chen, 2012. "Predictive effects of structural variation on citation counts," Journal of the Association for Information Science & Technology, Association for Information Science & Technology, vol. 63(3), pages 431-449, March.
    17. Lori Rosenkopf & Atul Nerkar, 2001. "Beyond local search: boundary‐spanning, exploration, and impact in the optical disk industry," Strategic Management Journal, Wiley Blackwell, vol. 22(4), pages 287-306, April.
    18. Alan L. Porter & Ismael Rafols, 2009. "Is science becoming more interdisciplinary? Measuring and mapping six research fields over time," Scientometrics, Springer;Akadémiai Kiadó, vol. 81(3), pages 719-745, December.
    19. Balconi, Margherita & Breschi, Stefano & Lissoni, Francesco, 2004. "Networks of inventors and the role of academia: an exploration of Italian patent data," Research Policy, Elsevier, vol. 33(1), pages 127-145, January.
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    Cited by:

    1. Anthony F J van Raan & Jos J Winnink, 2019. "The occurrence of ‘Sleeping Beauty’ publications in medical research: Their scientific impact and technological relevance," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-34, October.
    2. Winnink, J.J. & Tijssen, Robert J.W. & van Raan, A.F.J., 2019. "Searching for new breakthroughs in science: How effective are computerised detection algorithms?," Technological Forecasting and Social Change, Elsevier, vol. 146(C), pages 673-686.

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