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The Quality of Life and the Bio-Molecular Profile in Working Environment: A Systematic Review

Author

Listed:
  • Federica Ghelli

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Francesca Malandrone

    (Department of Clinical and Biological Sciences, University of Turin, 10043 Turin, Italy)

  • Valeria Bellisario

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Giulia Squillacioti

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Marco Panizzolo

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

  • Nicoletta Colombi

    (Federated Library of Medicine “F. Rossi”, University of Turin, 10126 Turin, Italy)

  • Luca Ostacoli

    (Department of Clinical and Biological Sciences, University of Turin, 10043 Turin, Italy)

  • Roberto Bono

    (Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy)

Abstract

Working life is characterised by various requirements and degrees of control in meeting these demands. The imbalance of these elements with workers’ resources can result in work-related stress involving the repeated activation of stress response systems. Modifications in the bio-molecular profile may represent a biological signature of individuals’ life experiences and provide evidence on pathways through which such stressors can result in health outcomes. The aim of our systematic review is to characterize the quality of life (QOL) and the bio-molecular profile in the working population, to highlight if the alteration observed might be related to the working conditions. The article query was performed on PubMed, Embase, and Cochrane CENTRAL and results have been presented according to three molecular pathways involved in the stress response: oxidative stress, inflammation, and neuroendocrine activation. The epidemiological sample has been sub-grouped into “clinical” and “non-clinical” populations according to the presence of a diagnosis of psychological disorders. Besides some critical issues, the review highlights the importance of developing a valid array of biological indicators, measurable in non-invasive matrices, sensitive to both derangements from physiological conditions and stress reduction, useful for identifying those groups at higher risk of health outcomes and, eventually, promoting workers’ wellbeing.

Suggested Citation

  • Federica Ghelli & Francesca Malandrone & Valeria Bellisario & Giulia Squillacioti & Marco Panizzolo & Nicoletta Colombi & Luca Ostacoli & Roberto Bono, 2022. "The Quality of Life and the Bio-Molecular Profile in Working Environment: A Systematic Review," Sustainability, MDPI, vol. 14(13), pages 1-22, July.
    • Handle: RePEc:gam:jsusta:v:14:y:2022:i:13:p:8100-:d:854410
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    References listed on IDEAS

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    1. repec:aph:ajpbhl:10.2105/ajph.2017.303840_1 is not listed on IDEAS
    2. Shockey, T.M. & Zack, M. & Sussell, A., 2017. "Health-related quality of life among US workers: Variability across occupation groups," American Journal of Public Health, American Public Health Association, vol. 107(8), pages 1316-1323.
    3. Isabelle Niedhammer & Jean-François Chastang & Hélène Sultan-Taïeb & Greet Vermeylen & Agnès Parent-Thirion, 2013. "Psychosocial work factors and sickness absence in 31 countries in Europe," Post-Print halshs-01228084, HAL.
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