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Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever

Author

Listed:
  • Ingrid Nordeide Kuiper

    (Department of Occupational Medicine, Haukeland University Hospital, 5020 Bergen, Norway
    Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway)

  • Iana Markevych

    (Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, 85764 Munich, Germany
    Institute of Psychology, Jagiellonian University, 30-060 Krakow, Poland
    Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 80336 Neuherberg, Germany)

  • Simone Accordini

    (Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy)

  • Randi J. Bertelsen

    (Department of Clinical Science, University of Bergen, 5020 Bergen, Norway
    Oral Health Centre of Expertise in Western Norway, 5020 Bergen, Norway)

  • Lennart Bråbäck

    (Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umea University, 901 87 Umea, Sweden)

  • Jesper Heile Christensen

    (Department of Environmental Science, Aarhus University, 4000 Roskilde, Denmark)

  • Bertil Forsberg

    (Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umea University, 901 87 Umea, Sweden)

  • Thomas Halvorsen

    (Department of Clinical Science, University of Bergen, 5020 Bergen, Norway)

  • Joachim Heinrich

    (Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, 85764 Munich, Germany
    Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne 3010, Australia)

  • Ole Hertel

    (Department of Environmental Science, Aarhus University, 4000 Roskilde, Denmark)

  • Gerard Hoek

    (Institute for Risk Assessment Sciences, Utrecht University, 3584 CS Utrecht, The Netherlands)

  • Mathias Holm

    (Department of Occupational and Environmental Medicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden)

  • Kees de Hoogh

    (Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland
    University of Basel, 4001 Basel, Switzerland)

  • Christer Janson

    (Department of Medical Sciences, Respiratory, Allergy & Sleep Research, Uppsala University, 751 85 Uppsala, Sweden)

  • Andrei Malinovschi

    (Department of Medical Sciences, Clinical Physiology, Uppsala University, 751 85 Uppsala, Sweden)

  • Alessandro Marcon

    (Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy)

  • Torben Sigsgaard

    (Section of Environment, Occupation & Health, Institute of Public Health, Aarhus University, 8000 Aarhus, Denmark)

  • Cecilie Svanes

    (Department of Occupational Medicine, Haukeland University Hospital, 5020 Bergen, Norway
    Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway
    These authors contributed equally to this work as last authors.)

  • Ane Johannessen

    (Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway
    These authors contributed equally to this work as last authors.)

Abstract

We investigated if greenness and air pollution exposure in parents’ childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM 2.5 and PM 10 ), nitrogen dioxide (NO 2 ), black carbon (BC), ozone (O 3 ) (µg/m 3 ) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0–18 years old and offspring 0–10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM 2.5 and PM 10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32–3.78, OR 2.27, 95%CI 1.36–3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11–0.87). Hay fever risk increased for offspring of fathers with medium O 3 exposure (OR 4.15, 95%CI 1.28–13.50) and mothers with high PM 10 exposure (OR 2.66, 95%CI 1.19–5.91). The effect of maternal PM 10 exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring’s own exposures. Paternal O 3 exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.

Suggested Citation

  • Ingrid Nordeide Kuiper & Iana Markevych & Simone Accordini & Randi J. Bertelsen & Lennart Bråbäck & Jesper Heile Christensen & Bertil Forsberg & Thomas Halvorsen & Joachim Heinrich & Ole Hertel & Gera, 2020. "Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever," IJERPH, MDPI, vol. 17(16), pages 1-14, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:16:p:5828-:d:397775
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    References listed on IDEAS

    as
    1. Giulia Squillacioti & Valeria Bellisario & Stefano Levra & Pavilio Piccioni & Roberto Bono, 2019. "Greenness Availability and Respiratory Health in a Population of Urbanised Children in North-Western Italy," IJERPH, MDPI, vol. 17(1), pages 1-11, December.
    2. Maarten L. Buis, 2010. "Direct and indirect effects in a logit model," Stata Journal, StataCorp LP, vol. 10(1), pages 11-29, March.
    3. Haneen Khreis & Mark J. Nieuwenhuijsen, 2017. "Traffic-Related Air Pollution and Childhood Asthma: Recent Advances and Remaining Gaps in the Exposure Assessment Methods," IJERPH, MDPI, vol. 14(3), pages 1-19, March.
    4. Katrina A. Lambert & Gayan Bowatte & Rachel Tham & Caroline J. Lodge & Luke A. Prendergast & Joachim Heinrich & Michael J. Abramson & Shyamali C. Dharmage & Bircan Erbas, 2018. "Greenspace and Atopic Sensitization in Children and Adolescents—A Systematic Review," IJERPH, MDPI, vol. 15(11), pages 1-12, November.
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    Cited by:

    1. Juan Pablo López-Cervantes & Marianne Lønnebotn & Nils Oskar Jogi & Lucia Calciano & Ingrid Nordeide Kuiper & Matthew G. Darby & Shyamali C. Dharmage & Francisco Gómez-Real & Barbara Hammer & Randi Ja, 2021. "The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?," IJERPH, MDPI, vol. 18(23), pages 1-20, December.
    2. Iana Markevych & Natasza Orlov & James Grellier & Katarzyna Kaczmarek-Majer & Małgorzata Lipowska & Katarzyna Sitnik-Warchulska & Yarema Mysak & Clemens Baumbach & Maja Wierzba-Łukaszyk & Munawar Huss, 2021. "NeuroSmog: Determining the Impact of Air Pollution on the Developing Brain: Project Protocol," IJERPH, MDPI, vol. 19(1), pages 1-19, December.

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