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Trends in Resistance to Extended-Spectrum Cephalosporins and Carbapenems among Escherichia coli and Klebsiella spp. Isolates in a District in Western India during 2004–2014

Author

Listed:
  • Ingvild Odsbu

    (Department of Public Health Sciences, Karolinska Institutet, 17177 Stockholm, Sweden
    These authors contributed equally to this work.)

  • Smita Khedkar

    (Bac-Test Laboratory, College Road, Nashik 422005, Maharashtra, India
    These authors contributed equally to this work.)

  • Frida Lind

    (Department of Public Health Sciences, Karolinska Institutet, 17177 Stockholm, Sweden)

  • Uday Khedkar

    (Bac-Test Laboratory, College Road, Nashik 422005, Maharashtra, India)

  • Sandeep S. Nerkar

    (Department of Public Health Sciences, Karolinska Institutet, 17177 Stockholm, Sweden
    Indian Initiative for Management of Antibiotic Resistance, Department of Environmental Medicine, R.D. Gardi Medical College, Ujjain 456006, India)

  • Nicola Orsini

    (Department of Public Health Sciences, Karolinska Institutet, 17177 Stockholm, Sweden)

  • Ashok J. Tamhankar

    (Department of Public Health Sciences, Karolinska Institutet, 17177 Stockholm, Sweden
    Indian Initiative for Management of Antibiotic Resistance, Department of Environmental Medicine, R.D. Gardi Medical College, Ujjain 456006, India)

  • Cecilia Stålsby Lundborg

    (Department of Public Health Sciences, Karolinska Institutet, 17177 Stockholm, Sweden)

Abstract

Surveillance data on the level of resistant bacteria is needed to inform strategies to reduce the development and spread of antibiotic resistance. The aim of this study was to determine the non-susceptibility trends to extended-spectrum cephalosporins and carbapenems among Escherichia coli and Klebsiella spp. isolates from the district of Nashik in Western India during the period 2004–2014. Antibacterial susceptibility testing of clinical isolates was performed using Kirby-Bauer disc diffusion method to determine inhibitory zone diameters. The change in proportions of non-susceptible bacteria over calendar time was investigated with spline transformations in a logistic regression model. For the extended-spectrum cephalosporins, the proportions of non-susceptible E. coli and Klebsiella spp. isolates were above 78.4% and 84.9% throughout the study period, respectively. E. coli and Klebsiella spp. isolates exhibited carbapenem non-susceptibility levels as high as 76.9% and 84.1% respectively. The proportions of extended-spectrum betalactamase (ESBL)-producing isolates ranged from 38.3–85.9% in E. coli and from 45.1–93.1% in Klebsiella spp. Significantly higher proportions of non-susceptible and ESBL-producing isolates were found among isolates from inpatients compared to isolates from outpatients for both E. coli and Klebsiella spp. ( p < 0.050). The high proportions of non-susceptible isolates observed show that there is great need to focus on optimal use of antibiotics to reduce the development of antibiotic resistance.

Suggested Citation

  • Ingvild Odsbu & Smita Khedkar & Frida Lind & Uday Khedkar & Sandeep S. Nerkar & Nicola Orsini & Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2018. "Trends in Resistance to Extended-Spectrum Cephalosporins and Carbapenems among Escherichia coli and Klebsiella spp. Isolates in a District in Western India during 2004–2014," IJERPH, MDPI, vol. 15(1), pages 1-15, January.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:1:p:155-:d:127767
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    References listed on IDEAS

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    1. Patrick Royston & Willi Sauerbrei, 2007. "Multivariable modeling with cubic regression splines: A principled approach," Stata Journal, StataCorp LP, vol. 7(1), pages 45-70, February.
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