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Optimal Voluntary Vaccination of Adults and Adolescents Can Help Eradicate Hepatitis B in China

Author

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  • Kristen Scheckelhoff

    (Department of Mathematics and Statistics, University of North Carolina at Greensboro, Greensboro, NC 27402, USA)

  • Ayesha Ejaz

    (Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402, USA)

  • Igor V. Erovenko

    (Department of Mathematics and Statistics, University of North Carolina at Greensboro, Greensboro, NC 27402, USA)

  • Jan Rychtář

    (Department of Mathematics and Applied Mathematics, Virginia Commonwealth University, Richmond, VA 23284, USA)

  • Dewey Taylor

    (Department of Mathematics and Applied Mathematics, Virginia Commonwealth University, Richmond, VA 23284, USA)

Abstract

Hepatitis B (HBV) is one of the most common infectious diseases, with a worldwide annual incidence of over 250 million people. About one-third of the cases are in China. While China made significant efforts to implement a nationwide HBV vaccination program for newborns, a significant number of susceptible adults and teens remain. In this paper, we analyze a game-theoretical model of HBV dynamics that incorporates government-provided vaccination at birth coupled with voluntary vaccinations of susceptible adults and teens. We show that the optimal voluntary vaccination brings the disease incidence to very low levels. This result is robust and, in particular, due to a high HBV treatment cost, essentially independent from the vaccine cost.

Suggested Citation

  • Kristen Scheckelhoff & Ayesha Ejaz & Igor V. Erovenko & Jan Rychtář & Dewey Taylor, 2021. "Optimal Voluntary Vaccination of Adults and Adolescents Can Help Eradicate Hepatitis B in China," Games, MDPI, vol. 12(4), pages 1-13, October.
  • Handle: RePEc:gam:jgames:v:12:y:2021:i:4:p:82-:d:664829
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    References listed on IDEAS

    as
    1. Cheol Yong Han & Habeeb Issa & Jan Rychtář & Dewey Taylor & Nancy Umana, 2020. "A voluntary use of insecticide treated nets can stop the vector transmission of Chagas disease," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(11), pages 1-19, November.
    2. Iwamura, Yoshiro & Tanimoto, Jun, 2018. "Realistic decision-making processes in a vaccination game," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 494(C), pages 236-241.
    3. Mehlika Toy & David W Hutton & Samuel K So, 2015. "Cost-Effectiveness and Cost Thresholds of Generic and Brand Drugs in a National Chronic Hepatitis B Treatment Program in China," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-19, November.
    4. Andrea Anonychuk & Andrea Tricco & Chris Bauch & Ba’ Pham & Vladimir Gilca & Bernard Duval & Ava John-Baptiste & Gloria Woo & Murray Krahn, 2008. "Cost-Effectiveness Analyses of Hepatitis A Vaccine," PharmacoEconomics, Springer, vol. 26(1), pages 17-32, January.
    5. Sykes, David & Rychtář, Jan, 2015. "A game-theoretic approach to valuating toxoplasmosis vaccination strategies," Theoretical Population Biology, Elsevier, vol. 105(C), pages 33-38.
    6. Huang, Jiechen & Wang, Juan & Xia, Chengyi, 2020. "Role of vaccine efficacy in the vaccination behavior under myopic update rule on complex networks," Chaos, Solitons & Fractals, Elsevier, vol. 130(C).
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    Cited by:

    1. Jabili Angina & Anish Bachhu & Eesha Talati & Rishi Talati & Jan Rychtář & Dewey Taylor, 2022. "Game-Theoretical Model of the Voluntary Use of Insect Repellents to Prevent Zika Fever," Dynamic Games and Applications, Springer, vol. 12(1), pages 133-146, March.
    2. Jovic Aaron S. Caasi & Brian M. Joseph & Heera J. Kodiyamplakkal & Jaelene Renae U. Manibusan & Leslie J. Camacho Aquino & Hyunju Oh & Jan Rychtář & Dewey Taylor, 2022. "A Game-Theoretic Model of Voluntary Yellow Fever Vaccination to Prevent Urban Outbreaks," Games, MDPI, vol. 13(4), pages 1-14, August.

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