IDEAS home Printed from https://ideas.repec.org/a/eee/proeco/v160y2015icp106-119.html
   My bibliography  Save this article

Network embeddedness and new product development in the biopharmaceutical industry: The moderating role of open innovation flow

Author

Listed:
  • Mazzola, Erica
  • Perrone, Giovanni
  • Kamuriwo, Dzidziso Samuel

Abstract

This paper explores the role of centrality and structural holes positions on the likelihood to develop new products and the moderating role of the open innovation flow, a measure of the net knowledge flow crossing the firm’s boundaries, on the aforementioned relation. We argue that network positions provide the information content to the firm, whilst open innovation flow describes how the firm uses such content, thus the combination of these two concepts has a significant impact on new product development. We test the theoretical framework on a large sample of 544 public companies and data from 1758 agreements among 1890 bio-pharmaceutical firms through the period 2006–2010. Our results show that being centrally located in the network positively affects the new product development process, while having a structural holes position has no effect on the aforementioned performance. However, the interaction of the two network positions with the open innovation flow has a positive impact on the likelihood to develop new products.

Suggested Citation

  • Mazzola, Erica & Perrone, Giovanni & Kamuriwo, Dzidziso Samuel, 2015. "Network embeddedness and new product development in the biopharmaceutical industry: The moderating role of open innovation flow," International Journal of Production Economics, Elsevier, vol. 160(C), pages 106-119.
    • Handle: RePEc:eee:proeco:v:160:y:2015:i:c:p:106-119
    DOI: 10.1016/j.ijpe.2014.10.002
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0925527314003168
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.ijpe.2014.10.002?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Mina, Andrea & Bascavusoglu-Moreau, Elif & Hughes, Alan, 2014. "Open service innovation and the firm's search for external knowledge," Research Policy, Elsevier, vol. 43(5), pages 853-866.
    2. Akbar Zaheer & Geoffrey G. Bell, 2005. "Benefiting from network position: firm capabilities, structural holes, and performance," Strategic Management Journal, Wiley Blackwell, vol. 26(9), pages 809-825, September.
    3. Dahlander, Linus & Gann, David M., 2010. "How open is innovation?," Research Policy, Elsevier, vol. 39(6), pages 699-709, July.
    4. Wim Vanhaverbeke & Victor Gilsing & Bonnie Beerkens & Geert Duysters, 2009. "The Role of Alliance Network Redundancy in the Creation of Core and Non‐core Technologies," Journal of Management Studies, Wiley Blackwell, vol. 46(2), pages 215-244, March.
    5. Soh, Pek-Hooi, 2003. "The role of networking alliances in information acquisition and its implications for new product performance," Journal of Business Venturing, Elsevier, vol. 18(6), pages 727-744, November.
    6. Peter Moran, 2005. "Structural vs. relational embeddedness: social capital and managerial performance," Strategic Management Journal, Wiley Blackwell, vol. 26(12), pages 1129-1151, December.
    7. He, Yuanqiong & Keung Lai, Kin & Sun, Hongyi & Chen, Yun, 2014. "The impact of supplier integration on customer integration and new product performance: The mediating role of manufacturing flexibility under trust theory," International Journal of Production Economics, Elsevier, vol. 147(PB), pages 260-270.
    8. Kartik Kalaignanam & Venkatesh Shankar & Rajan Varadarajan, 2007. "Asymmetric New Product Development Alliances: Win-Win or Win-Lose Partnerships?," Management Science, INFORMS, vol. 53(3), pages 357-374, March.
    9. Wim Vanhaverbeke & Geert Duysters & Niels Noorderhaven, 2002. "External Technology Sourcing Through Alliances or Acquisitions: An Analysis of the Application-Specific Integrated Circuits Industry," Organization Science, INFORMS, vol. 13(6), pages 714-733, December.
    10. Gilsing, Victor & Nooteboom, Bart & Vanhaverbeke, Wim & Duysters, Geert & van den Oord, Ad, 2008. "Network embeddedness and the exploration of novel technologies: Technological distance, betweenness centrality and density," Research Policy, Elsevier, vol. 37(10), pages 1717-1731, December.
    11. Nooteboom, B. & Gilsing, V.A., 2004. "Density And Strength Of Ties In Innovation Networks: A Competence And Governance View," ERIM Report Series Research in Management ERS-2004-005-ORG, Erasmus Research Institute of Management (ERIM), ERIM is the joint research institute of the Rotterdam School of Management, Erasmus University and the Erasmus School of Economics (ESE) at Erasmus University Rotterdam.
    12. Edward C. Norton & Hua Wang & Chunrong Ai, 2004. "Computing interaction effects and standard errors in logit and probit models," Stata Journal, StataCorp LP, vol. 4(2), pages 154-167, June.
    13. Tomlinson, Philip R. & Fai, Felicia M., 2013. "The nature of SME co-operation and innovation: A multi-scalar and multi-dimensional analysis," International Journal of Production Economics, Elsevier, vol. 141(1), pages 316-326.
    14. Erica Mazzola & Manfredi Bruccoleri & Giovanni Perrone, 2012. "The Effect Of Inbound, Outbound And Coupled Innovation On Performance," International Journal of Innovation Management (ijim), World Scientific Publishing Co. Pte. Ltd., vol. 16(06), pages 1-27.
    15. Rothaermel, Frank T., 2001. "Complementary assets, strategic alliances, and the incumbent's advantage: an empirical study of industry and firm effects in the biopharmaceutical industry," Research Policy, Elsevier, vol. 30(8), pages 1235-1251, October.
    16. Prashant Kale & Harbir Singh, 2007. "Building firm capabilities through learning: the role of the alliance learning process in alliance capability and firm‐level alliance success," Strategic Management Journal, Wiley Blackwell, vol. 28(10), pages 981-1000, October.
    17. Balaji R. Koka & John E. Prescott, 2008. "Designing alliance networks: the influence of network position, environmental change, and strategy on firm performance," Strategic Management Journal, Wiley Blackwell, vol. 29(6), pages 639-661, June.
    18. Donna Marie DeCarolis & David L. Deeds, 1999. "The impact of stocks and flows of organizational knowledge on firm performance: an empirical investigation of the biotechnology industry," Strategic Management Journal, Wiley Blackwell, vol. 20(10), pages 953-968, October.
    19. Malik, Tariq, 2012. "Disparate association between alliance social capital and the global pharmaceutical firm's performance," International Business Review, Elsevier, vol. 21(6), pages 1017-1028.
    20. Anthony Goerzen, 2007. "Alliance networks and firm performance: The impact of repeated partnerships," Strategic Management Journal, Wiley Blackwell, vol. 28(5), pages 487-509, May.
    21. Pérez-Luño, Ana & Cabello Medina, Carmen & Carmona Lavado, Antonio & Cuevas Rodríguez, Gloria, 2011. "How social capital and knowledge affect innovation," Journal of Business Research, Elsevier, vol. 64(12), pages 1369-1376.
    22. Gilsing, V. & Nooteboom, B., 2004. "Density and strength of ties in innovation networks: an analysis of multimedia and biotechnology," Working Papers 04.16, Eindhoven Center for Innovation Studies.
    23. Corey C. Phelps, 2010. "A longitudinal study of the influence of alliance network structure and composition on firm exploratory innovation," Post-Print hal-00528392, HAL.
    24. Dahlander, Linus & Piezunka, Henning, 2014. "Open to suggestions: How organizations elicit suggestions through proactive and reactive attention," Research Policy, Elsevier, vol. 43(5), pages 812-827.
    25. Jaider Vega-Jurado & Antonio Gutiérrez-Gracia & Ignacio Fernández-de-Lucio, 2009. "Does external knowledge sourcing matter for innovation? Evidence from the Spanish manufacturing industry," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 18(4), pages 637-670, August.
    26. Mazzola, Erica & Perrone, Giovanni, 2013. "A strategic needs perspective on operations outsourcing and other inter-firm relationships," International Journal of Production Economics, Elsevier, vol. 144(1), pages 256-267.
    27. Frank T. Rothaermel & David L. Deeds, 2004. "Exploration and exploitation alliances in biotechnology: a system of new product development," Strategic Management Journal, Wiley Blackwell, vol. 25(3), pages 201-221, March.
    28. Joseph A. DiMasi & Henry G. Grabowski, 2007. "The cost of biopharmaceutical R&D: is biotech different?," Managerial and Decision Economics, John Wiley & Sons, Ltd., vol. 28(4-5), pages 469-479.
    29. Melissa A. Schilling & Corey C. Phelps, 2007. "Interfirm Collaboration Networks: The Impact of Large-Scale Network Structure on Firm Innovation," Management Science, INFORMS, vol. 53(7), pages 1113-1126, July.
    30. Tsai, Kuen-Hung, 2009. "Collaborative networks and product innovation performance: Toward a contingency perspective," Research Policy, Elsevier, vol. 38(5), pages 765-778, June.
    31. Moses Acquaah, 2007. "Managerial social capital, strategic orientation, and organizational performance in an emerging economy," Strategic Management Journal, Wiley Blackwell, vol. 28(12), pages 1235-1255, December.
    32. Glenn Hoetker, 2007. "The use of logit and probit models in strategic management research: Critical issues," Strategic Management Journal, Wiley Blackwell, vol. 28(4), pages 331-343, April.
    33. Belderbos, René & Cassiman, Bruno & Faems, Dries & Leten, Bart & Van Looy, Bart, 2014. "Co-ownership of intellectual property: Exploring the value-appropriation and value-creation implications of co-patenting with different partners," Research Policy, Elsevier, vol. 43(5), pages 841-852.
    34. Wei‐ping Wu, 2008. "Dimensions of Social Capital and Firm Competitiveness Improvement: The Mediating Role of Information Sharing," Journal of Management Studies, Wiley Blackwell, vol. 45(1), pages 122-146, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yan, Tingting & Azadegan, Arash, 2017. "Comparing inter-organizational new product development strategies: Buy or ally; Supply-chain or non-supply-chain partners?," International Journal of Production Economics, Elsevier, vol. 183(PA), pages 21-38.
    2. Wang, Qiang & Zhao, Xiande & Voss, Chris, 2016. "Customer orientation and innovation: A comparative study of manufacturing and service firms," International Journal of Production Economics, Elsevier, vol. 171(P2), pages 221-230.
    3. Inhye Yoo & Chan-Goo Yi, 2022. "Economic Innovation Caused by Digital Transformation and Impact on Social Systems," Sustainability, MDPI, vol. 14(5), pages 1-18, February.
    4. Jiaping Xie & Haicheng Jia & Qi Dong & Gulizhaer Aisaiti, 2022. "Research on the Governance Mechanism of Independent Innovation Network in the Core Area of Silk Road Economic Belt," Sustainability, MDPI, vol. 14(13), pages 1-24, June.
    5. (Daniel) Kao, Ta-Wei & Su, Hung-Chung & Chen, Yi-Su, 2019. "The curvilinear relationships between structural embeddedness and productive efficiency: An exploratory study," International Journal of Production Economics, Elsevier, vol. 212(C), pages 176-185.
    6. Laurence Saglietto & Cécile Cézanne & Delphine David, 2020. "Research On Structural Holes: An Assessment On Measurement Issues," Journal of Economic Surveys, Wiley Blackwell, vol. 34(3), pages 572-593, July.
    7. Babbar, Sunil & Behara, Ravi S. & Koufteros, Xenophon A. & Wong, Christina W.Y., 2018. "Charting leadership in SCM research from Asia and Europe," International Journal of Production Economics, Elsevier, vol. 203(C), pages 350-378.
    8. Babbar, Sunil & Behara, Ravi S. & Koufteros, Xenophon A. & Huo, Baofeng, 2017. "Emergence of Asia and Australasia in operations management research and leadership," International Journal of Production Economics, Elsevier, vol. 184(C), pages 80-94.
    9. Suh, Yongyoon & Jeon, Jeonghwan, 2019. "Monitoring patterns of open innovation using the patent-based brokerage analysis," Technological Forecasting and Social Change, Elsevier, vol. 146(C), pages 595-605.
    10. Mazzola, Erica & Perrone, Giovanni & Kamuriwo, Dzidziso Samuel, 2016. "The interaction between inter-firm and interlocking directorate networks on firm's new product development outcomes," Journal of Business Research, Elsevier, vol. 69(2), pages 672-682.
    11. Dong-Young Kim & Pengcheng Zhu & Wenli Xiao & Yen-Ting Lin, 2020. "Customer degree centrality and supplier performance: the moderating role of resource dependence," Operations Management Research, Springer, vol. 13(1), pages 22-38, June.
    12. Lyu, Yibo & Zhu, Yuqing & Han, Shaojie & He, Binyuan & Bao, Lining, 2020. "Open innovation and innovation "Radicalness"—the moderating effect of network embeddedness," Technology in Society, Elsevier, vol. 62(C).
    13. Yonghong Ma & Xiaomeng Yang & Sen Qu & Lingkai Kong, 2022. "Research on the formation mechanism of big data technology cooperation networks: empirical evidence from China," Scientometrics, Springer;Akadémiai Kiadó, vol. 127(3), pages 1273-1294, March.
    14. Vendrell-Herrero, Ferran & Bustinza, Oscar F. & Opazo-Basaez, Marco, 2021. "Information technologies and product-service innovation: The moderating role of service R&D team structure," Journal of Business Research, Elsevier, vol. 128(C), pages 673-687.
    15. Wan, Qunchao & Tang, Shiyi & Jiang, Zhenwu, 2023. "Does the development of digital technology contribute to the innovation performance of China's high-tech industry？," Technovation, Elsevier, vol. 124(C).
    16. Vendrell-Herrero, Ferran & Bustinza, Oscar F. & Opazo-Basaez, Marco & Gomes, Emanuel, 2023. "Treble innovation firms: Antecedents, outcomes, and enhancing factors," International Journal of Production Economics, Elsevier, vol. 255(C).
    17. Yan, Tingting & Wagner, Stephan M., 2017. "Do what and with whom? Value creation and appropriation in inter-organizational new product development projects," International Journal of Production Economics, Elsevier, vol. 191(C), pages 1-14.
    18. Xuan Wei & Wei Chen, 2019. "How Does A Firm’s Previous Social Network Position Affect Innovation? Evidence from Chinese Listed Companies," Sustainability, MDPI, vol. 11(4), pages 1-20, February.
    19. Hugo Ernesto Martínez Ardila & Julián Eduardo Mora Moreno & Jaime Alberto Camacho Pico, 2020. "Networks of collaborative alliances: the second order interfirm technological distance and innovation performance," The Journal of Technology Transfer, Springer, vol. 45(4), pages 1255-1282, August.
    20. Lyu, Yibo & He, Binyuan & Zhu, Yuqing & Li, Li, 2019. "Network embeddedness and inbound open innovation practice: The moderating role of technology cluster," Technological Forecasting and Social Change, Elsevier, vol. 144(C), pages 12-24.
    21. Choi, Tsan-Ming, 2018. "Launching the right new product among multiple product candidates in fashion: Optimal choice and coordination with risk consideration," International Journal of Production Economics, Elsevier, vol. 202(C), pages 162-171.
    22. Sharma, Amalesh & Pathak, Surya & Borah, Sourav Bikash & Adhikary, Anirban, 2022. "Collaboration strategies in buyer-supplier relational (BSR) networks and sustainable firm performance: A trade-off story," International Journal of Production Economics, Elsevier, vol. 253(C).
    23. Dapeng Zhang & Xinbo Sun & Yide Liu & Shunyi Zhou & Hongfeng Zhang, 2018. "The Effects of Integrative Leadership on the Enterprise Synergy Innovation Performance in a Supply Chain Cooperative Network," Sustainability, MDPI, vol. 10(7), pages 1-20, July.
    24. Chen, Feiqiong & Liu, Huiqian & Ge, Yuhao, 2021. "How does integration affect industrial innovation through networks in technology-sourcing overseas M&A? A comparison between China and the US," Journal of Business Research, Elsevier, vol. 122(C), pages 281-292.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mazzola, Erica & Perrone, Giovanni & Kamuriwo, Dzidziso Samuel, 2016. "The interaction between inter-firm and interlocking directorate networks on firm's new product development outcomes," Journal of Business Research, Elsevier, vol. 69(2), pages 672-682.
    2. Hugo Ernesto Martínez Ardila & Julián Eduardo Mora Moreno & Jaime Alberto Camacho Pico, 2020. "Networks of collaborative alliances: the second order interfirm technological distance and innovation performance," The Journal of Technology Transfer, Springer, vol. 45(4), pages 1255-1282, August.
    3. Haifeng Wang & Longwei Tian & Yuan Li, 2019. "A tale of two cultures: Social networks and competitive advantage," Asia Pacific Journal of Management, Springer, vol. 36(2), pages 321-347, June.
    4. Lyu, Yibo & He, Binyuan & Zhu, Yuqing & Li, Li, 2019. "Network embeddedness and inbound open innovation practice: The moderating role of technology cluster," Technological Forecasting and Social Change, Elsevier, vol. 144(C), pages 12-24.
    5. Bilicz, Dávid, 2021. "A hálózatok és a kapcsolatok szerepe az innovációban és a tudás áramlásában. Szisztematikus szakirodalmi áttekintés [The role of networks and partnerships in innovation and knowledge flow - a syste," Közgazdasági Szemle (Economic Review - monthly of the Hungarian Academy of Sciences), Közgazdasági Szemle Alapítvány (Economic Review Foundation), vol. 0(6), pages 674-698.
    6. Jacob, Jojo & Duysters, Geert, 2017. "Alliance network configurations and the co-evolution of firms' technology profiles: An analysis of the biopharmaceutical industry," Technological Forecasting and Social Change, Elsevier, vol. 120(C), pages 90-102.
    7. Aurora Liu Genin & Justin Tan & Juan Song, 2022. "Relational assets or liabilities? Competition, collaboration, and firm intellectual property breakthrough in the Chinese high-speed train sector," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 53(9), pages 1895-1923, December.
    8. Rogbeer, Shalini & Almahendra, Rangga & Ambos, Björn, 2014. "Open-Innovation Effectiveness: When does the Macro Design of Alliance Portfolios Matter?," Journal of International Management, Elsevier, vol. 20(4), pages 464-477.
    9. Gilsing, Victor & Nooteboom, Bart & Vanhaverbeke, Wim & Duysters, Geert & van den Oord, Ad, 2008. "Network embeddedness and the exploration of novel technologies: Technological distance, betweenness centrality and density," Research Policy, Elsevier, vol. 37(10), pages 1717-1731, December.
    10. Lee, Cheng-Yu & Wang, Ming-Chao & Huang, Yen-Chih, 2015. "The double-edged sword of technological diversity in R&D alliances: Network position and learning speed as moderators," European Management Journal, Elsevier, vol. 33(6), pages 450-461.
    11. Yue Zhao & Ronaldo Parente & Stav Fainshmidt & Steven Carnovale, 2021. "MNE host-country alliance network position and post-entry establishment mode choice," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 52(7), pages 1350-1364, September.
    12. Casanueva, Cristóbal & Castro, Ignacio & Galán, José L., 2013. "Informational networks and innovation in mature industrial clusters," Journal of Business Research, Elsevier, vol. 66(5), pages 603-613.
    13. Na Zhang & Lu Cheng & Chao Sun & Julie Callaert & Bart Looy, 2023. "The role of inter- and intra-organisational networks in innovation: towards requisite variety," Scientometrics, Springer;Akadémiai Kiadó, vol. 128(7), pages 4117-4136, July.
    14. Mao, Chongfeng & Yu, Xianyun & Zhou, Qing & Harms, Rainer & Fang, Gang, 2020. "Knowledge growth in university-industry innovation networks – Results from a simulation study," Technological Forecasting and Social Change, Elsevier, vol. 151(C).
    15. Wim Vanhaverbeke & Victor Gilsing & Bonnie Beerkens & Geert Duysters, 2009. "The Role of Alliance Network Redundancy in the Creation of Core and Non‐core Technologies," Journal of Management Studies, Wiley Blackwell, vol. 46(2), pages 215-244, March.
    16. Guan, Jiancheng & Liu, Na, 2016. "Exploitative and exploratory innovations in knowledge network and collaboration network: A patent analysis in the technological field of nano-energy," Research Policy, Elsevier, vol. 45(1), pages 97-112.
    17. Gilsing, Victor A. & Cloodt, Myriam & Bertrand–Cloodt, Danielle, 2016. "What makes you more central? Antecedents of changes in betweenness-centrality in technology-based alliance networks," Technological Forecasting and Social Change, Elsevier, vol. 111(C), pages 209-221.
    18. Yanfeng Zheng & Haibin Yang, 2015. "Does Familiarity Foster Innovation? The Impact of Alliance Partner Repeatedness on Breakthrough Innovations," Journal of Management Studies, Wiley Blackwell, vol. 52(2), pages 213-230, March.
    19. Mazzola, Erica & Bruccoleri, Manfredi & Perrone, Giovanni, 2019. "The curvilinear effect of manufacturing outsourcing and captive-offshoring on firms' innovation: The role of temporal endurance," International Journal of Production Economics, Elsevier, vol. 211(C), pages 197-210.
    20. Haifeng Wang & Pengfei Han & Weishu Liu, 2018. "How to Improve Sustainable Competitive Advantage from the Distributor and the Supplier Networks: Evidence from the Paper-Making Industry in China," Sustainability, MDPI, vol. 10(6), pages 1-13, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:proeco:v:160:y:2015:i:c:p:106-119. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/ijpe .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.